5-Fluorouracil Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 51-21-8 |
| Product name | 5-Fluorouracil |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 5-Fluorouracil
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Fluorouracil Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Fluorouracil
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Antitumor agent for treating various solid tumors, including colorectal cancer, breast cancer, gastric cancer, and pancreatic cancer | Used as a nucleotide analog to inhibit thymidylate synthase, thereby interfering with DNA synthesis and suppressing tumor cell proliferation |
| Pharmaceuticals | Topical treatment for skin cancers (e.g., basal cell carcinoma) and precancerous lesions (e.g., actinic keratosis) | Applied topically as a cream or solution to target affected tissue via local penetration, inducing apoptosis of abnormal cells |
| Pharmaceuticals | Ophthalmic use to prevent scar formation following glaucoma filtration surgery | Applied locally during or after surgery to inhibit fibroblast proliferation and reduce scarring of the filtration pathway |
| Research | Tool compound in molecular biology and pharmacological studies | Used in in vitro cell assays or animal models to investigate pyrimidine metabolism, DNA synthesis mechanisms, and modes of action of anticancer drugs |
Manufacturing Quality Control of 5-Fluorouracil
| Detection Item | Common Detection Method | Method Overview |
|---|---|---|
| Identification | Ultraviolet-Visible Spectrophotometry (UV-Vis) | The compound 5-fluorouracil exhibits a characteristic absorption peak around 265 nm. Qualitative identification is performed by comparing the spectrum with a standard reference. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | A reverse-phase C18 column is used with methanol-water or buffer salt as the mobile phase. The main peak is detected using a UV detector at approximately 265 nm. Quantification is performed using an external standard method, which offers high accuracy and strong specificity. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | The same conditions as content determination or optimized gradient elution programs are used to separate and detect synthetic intermediates, degradation products, and other impurities. Impurity content is calculated using normalization of peak areas or comparison with reference standards. |
| Solution Clarity and Color | Visual Colorimetry | The sample solution is prepared at the specified concentration and compared with standard turbidity and color comparison solutions to determine clarity and colorlessness. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Atmospheric Drying | The sample is dried at 105°C until constant weight is reached, and the percentage of weight loss is determined to control water of crystallization or residual solvent content. |
| Residue on Ignition | Sulfuric Acid Treatment Followed by High-Temperature Ignition | The sample is treated with sulfuric acid and then ignited at 700–800°C. The weight of the residue is measured to control inorganic impurity content. |
| Heavy Metals | Thioacetamide Method (Chinese Pharmacopoeia) | Under weakly acidic conditions, heavy metals react with thioacetamide to form colored sulfides. The intensity of the color is compared with that of a standard lead solution for limit testing. |
| Fluoride Ion Content | Ion Chromatography (IC) or Fluoride Ion-Selective Electrode Method | This method detects free fluoride ions in the drug to verify the stability of the fluorine atom and monitor its degradation, ensuring structural integrity. |
| Solubility | Solubility Test | The solubility behavior of 5-fluorouracil in water, ethanol, dilute acid, and dilute alkali is observed, and it should conform to pharmacopoeia descriptions. |
| Crystalline Form Analysis | X-ray Powder Diffraction (XRD) | The crystal structure of solid samples is analyzed to confirm the presence of polymorphs and ensure batch consistency. |
| Moisture Content | Karl Fischer Titration | This method precisely determines the amount of bound or free water in the sample, suitable for trace moisture analysis to ensure stability. |
Technical Specifications of 5-Fluorouracil
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.5% (HPLC) |
| Melting Point | 282-284°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.3% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 5-Fluorouracil
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Fluorouracil
Packaging of 5-Fluorouracil
Industrial 5-Fluorouracil Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply