19-HYDROXY-4-ANDROSTENE-3,17-DIONE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 510-64-5 |
| Product name | 19-HYDROXY-4-ANDROSTENE-3,17-DIONE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 19-HYDROXY-4-ANDROSTENE-3,17-DIONE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Manufacturing | Key intermediate for synthesizing glucocorticoids (e.g., prednisolone) and sex hormones (e.g., testosterone) | Multi-step reactions—including microbial transformation (e.g., 11β-hydroxylation using Rhizopus nigricans or Streptomyces spp.) or chemical reduction/oxidation—to convert 19-hydroxyandrost-4-ene-3,17-dione into target active molecules |
| Biotechnology Research | Substrate for studying steroid metabolic pathways and substrate specificity/catalytic mechanisms of cytochrome P450 enzymes (e.g., CYP11B1, CYP19 aromatase) | In vitro enzyme kinetic assays, recombinant enzyme incubations, and isotopic labeling to trace metabolic products |
| Diagnostics Reagent Development | Reference standard or calibrant for LC-MS/MS or immunoassay quantification of endogenous steroid metabolites in urine or serum | High-purity crystalline material, certified with NIST-traceable values, used to establish calibration curves for clinical testing methods |
Manufacturing Quality Control of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
| Detection Item | Common Detection Method | Method Overview |
|---|---|---|
| Chemical Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Analyze hydrogen and carbon atoms in the compound using 1H-NMR and 13C-NMR to determine chemical shifts, confirming the molecular skeleton and substituent positions, and verifying the target structure. |
| Molecular Weight and Purity Identification | Mass Spectrometry (MS) | Use High-Resolution Mass Spectrometry (HRMS) or Liquid Chromatography-Mass Spectrometry (LC-MS) to determine molecular ion peaks, confirming molecular weight and fragment characteristics, and assisting in purity assessment. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a C18 reverse-phase column with a UV detector (e.g., 210–254 nm), and quantify the main component content using external standard method or area normalization. |
| Related Substances/Impurity Analysis | High-Performance Liquid Chromatography (HPLC) | Optimize gradient elution conditions to separate the main peak from potential impurity peaks, calculate the relative content of each impurity by peak area, and ensure compliance with pharmacopoeia limits (e.g., <0.5%). |
| Melting Point Determination | Capillary Melting Point Apparatus Method | Determine the melting temperature range of the sample, which serves as a physical constant for preliminary identification and purity judgment (pure substances typically have sharp melting ranges). |
| Drying Loss | Drying Method (105°C constant weight) | Weigh the sample and dry it in a constant temperature drying oven until constant weight is achieved, calculating the percentage of mass loss to control moisture and volatile impurities. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace injection or direct injection, with a polar capillary column (e.g., DB-624), and an FID detector to quantitatively analyze residual organic solvents (e.g., methanol, ethyl acetate, etc.). |
| Heavy Metal Testing | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | Dissolve the sample and measure the residual levels of elements such as lead, arsenic, cadmium, and mercury, ensuring compliance with ICH Q3D or pharmacopoeia limits (e.g., ≤10–20 ppm). |
| Specific Rotation | Polarimeter Measurement | Determine the optical rotation at a specified wavelength (e.g., sodium D line, 589 nm) and concentration, used for identity confirmation and purity assessment of chiral compounds. |
| Ultraviolet Absorption Spectra | UV-Visible Spectrophotometry (UV-Vis) | Scan the absorption curve in the 200–400 nm range to confirm characteristic absorption peaks (e.g., Δ⁴-3-ketone structure around 240 nm), used for identification and stability indication. |
Technical Specifications of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
| Test Item | Specification |
|---|---|
| Appearance | White powder |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 168–172°C |
| Optical Rotation | +185 to +195° (c=1, in CHCl3) |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
Safety Information of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
Industrial 19-HYDROXY-4-ANDROSTENE-3,17-DIONE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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