Estra-4,9-diene-3,17-dione Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 5173-46-6 |
| Product name | Estra-4,9-diene-3,17-dione |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Estra-4,9-diene-3,17-dione
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Estra-4,9-diene-3,17-dione Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Estra-4,9-diene-3,17-dione
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of steroid drugs (e.g., norethandrolone, drospirenone) | Biocatalytic or chemical synthesis for structural modification and functional group introduction |
| Research & Development | Reference standard or starting material for novel steroid hormone drug development | Laboratory-scale synthesis and purification for pharmacological activity screening |
| Biotechnology | Substrate or product in enzymatic or microbial transformation studies | Selective dehydrogenation or hydroxylation using microorganisms or enzymes |
Manufacturing Quality Control of Estra-4,9-diene-3,17-dione
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 column with methanol-water or acetonitrile-water as the mobile phase for gradient elution, detected by UV detector (240–280 nm). The external standard method is used to calculate the main component content, suitable for high-precision quantitative analysis. |
| Related Substances (Impurity) Testing | High-Performance Liquid Chromatography (HPLC) | Same as above; by extending run time or optimizing gradient program, potential synthesis intermediates and degradation products are separated and detected. Total impurities are typically required to be ≤0.5%. |
| Residual Solvents | Gas Chromatography (GC) | Based on ICH Q3C guidelines, detects organic solvents used during production (e.g., methanol, acetone, ethyl acetate). Uses capillary columns and flame ionization detection (FID), with headspace injection mode, ensuring residual levels comply with specified limits. |
| Polymorphic Analysis | X-Ray Powder Diffraction (XRD) | Used to identify different polymorphs and ensure consistency in crystal form; characteristic diffraction peak positions and intensities allow for qualitative identification and control of polymorphic forms. |
| Melting Point | Capillary Melting Point Method | Determined using a melting point apparatus, measuring the melting temperature range as an initial indicator of purity and substance characteristics. The typical melting point of this compound is approximately 180–185°C (varies depending on specific literature). |
| Water Content | Karl Fischer Titration (Karl Fischer) | Accurately measures water content in samples, available in either volumetric or coulometric methods, suitable for controlling loss on drying and stability of active pharmaceutical ingredients. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Method | Dried at a specified temperature (e.g., 105°C) for a defined period, weight loss is measured to assess volatile components and solvent residues. |
| Infrared Spectroscopy Identification (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Samples are analyzed as KBr pellets or using ATR accessory to obtain infrared absorption spectra, which are compared with reference spectra to confirm functional group consistency. |
| UV Absorption Characteristics | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Measures maximum absorption wavelength (λmax ≈ around 240 nm) in ethanol or methanol solution, used for auxiliary identification and preliminary screening of content. |
| Particle Size Distribution | Laser Particle Size Analysis | Used for particle size control of raw materials prior to formulation; affects dissolution rate and bioavailability. D10, D50, D90 parameters are determined after wet dispersion. |
Technical Specifications of Estra-4,9-diene-3,17-dione
| Test Item | Specification |
|---|---|
| Appearance | Green to orange to white powder or crystals |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148°C to 152°C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Estra-4,9-diene-3,17-dione
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of Estra-4,9-diene-3,17-dione
Industrial Estra-4,9-diene-3,17-dione Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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