2-Bromo-3-pyridinecarboxylic acid methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 52718-95-3 |
| Product name | 2-Bromo-3-pyridinecarboxylic acid methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-Bromo-3-pyridinecarboxylic acid methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Bromo-3-pyridinecarboxylic acid methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Bromo-3-pyridinecarboxylic acid methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pyridine-based pharmaceutical intermediates | Serves as a key synthetic building block for constructing pyridine-containing drug molecules, e.g., in the development of analgesics, anti-inflammatory agents, or antiviral drugs. |
| Agrochemicals | Agrochemical intermediates | Used to synthesize pyridine-containing insecticides or herbicides; the carboxylate ester and bromo substituent enable subsequent coupling or derivatization reactions. |
| Organic Synthesis | Substrate for Suzuki coupling reactions | Undergoes palladium-catalyzed cross-coupling with arylboronic acids via the bromo substituent to form bipyridyl or arylpyridyl derivatives. |
| Organic Synthesis | Precursor for ester derivatization | Hydrolyzed to 2-bromo-3-pyridinecarboxylic acid or subjected to transesterification to yield alternative ester derivatives for complex molecule synthesis. |
Manufacturing Quality Control of 2-Bromo-3-pyridinecarboxylic acid methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., starting materials, intermediates, isomers, degradants) using gradient HPLC-UV with system suitability criteria per ICH Q2(R2). |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., methanol, dichloromethane, toluene) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with water in anhydrous medium. |
| Heavy Metals | ICP-MS | Quantification of elemental impurities (e.g., Pb, Cd, Hg, As) after acid digestion, per ICH Q3D, using high-sensitivity mass spectrometric detection. |
| Chloride Impurity | Ion Chromatography (IC) | Separation and quantification of chloride ions using suppressed conductivity detection after sample dissolution and filtration. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement by observing solid-to-liquid phase change under controlled heating rate (e.g., 1–2 °C/min). |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to assess chiral purity (if applicable; compound is achiral but method included for potential enantiomeric contaminants). |
| Residue on Ignition | Gravimetric Analysis | Determination of inorganic residue after high-temperature ashing (700–800 °C) and weighing of residual ash. |
| Appearance (Color & Clarity) | Visual Inspection in Solution | Assessment of solution clarity and color (e.g., in methanol or acetonitrile) against standard references (e.g., APHA/Hazen scale). |
Technical Specifications of 2-Bromo-3-pyridinecarboxylic acid methyl ester
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.5% (LC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 68–72°C |
| Identification (NMR) | Conforms to reference standard |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-Bromo-3-pyridinecarboxylic acid methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Bromo-3-pyridinecarboxylic acid methyl ester
Safety Information of 2-Bromo-3-pyridinecarboxylic acid methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2-Bromo-3-pyridinecarboxylic acid methyl ester
Industrial 2-Bromo-3-pyridinecarboxylic acid methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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