2',3',4'-TRIHYDROXYACETOPHENONE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 528-21-2 |
| Product name | 2',3',4'-TRIHYDROXYACETOPHENONE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2',3',4'-TRIHYDROXYACETOPHENONE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2',3',4'-TRIHYDROXYACETOPHENONE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2',3',4'-TRIHYDROXYACETOPHENONE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthetic intermediate for catecholamine drugs (e.g., epinephrine, norepinephrine) | Chemical synthesis |
| Pharmaceuticals | Starting material for total synthesis of natural products or pharmaceuticals (e.g., salidroside) | Chemical synthesis |
| Chemical analysis | Colorimetric reagent or chelating agent for detection or quantification of trace metal ions (e.g., iron, copper) | Photometric analysis |
| Agriculture | Synthetic intermediate for plant growth regulators or specific agrochemicals | Chemical synthesis |
| Organic synthesis | Building block for other fine chemicals and complex organic molecules | Condensation and oxidation reactions |
Manufacturing Quality Control of 2',3',4'-TRIHYDROXYACETOPHENONE
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity and Content Determination | High-Performance Liquid Chromatography (HPLC) | An HPLC system with a C18 reversed-phase column is used, with methanol-water or acetonitrile-water (containing a small amount of acid such as formic acid) as the mobile phase. Detection is performed using a UV detector at wavelengths between 254–280 nm. Quantification is achieved by external or internal standard methods, allowing accurate determination of the active ingredient content and impurity levels. |
| Structural Confirmation | Infrared Spectroscopy (IR) | The presence of functional groups such as hydroxyl (~3200–3600 cm⁻¹), carbonyl (~1650 cm⁻¹), and aromatic rings (~1500–1600 cm⁻¹) is confirmed by analyzing the characteristic infrared absorption peaks, which helps verify the molecular structure. |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (¹H-NMR / ¹³C-NMR) | Measurements are carried out in DMSO-d₆ or CD₃OD. The chemical environment of hydrogen and carbon atoms in the molecule is analyzed through proton NMR chemical shifts (e.g., phenolic hydroxyl δ 8–10 ppm, aromatic protons δ 6–8 ppm) and characteristic carbon signals in the ¹³C-NMR spectrum, allowing precise structural elucidation and confirmation of substitution positions. |
| Water Content | Karl Fischer Titration | This method uses a reagent composed of iodine, sulfur dioxide, pyridine, and methanol that reacts quantitatively with water. Water content is determined by potentiometric or coulometric methods, suitable for controlling the impact of trace moisture on drug stability and solubility. |
| Melting Point | Melting Point Apparatus | The melting temperature range of the sample is determined using the capillary method or an automatic melting point apparatus (literature value approximately 120–125°C). It is used for preliminary purity assessment, as impurities often cause a depression or broadening of the melting point range. |
| Impurity Profile Analysis | HPLC-MS (Liquid Chromatography-Mass Spectrometry) | Based on HPLC separation, the molecular weight and fragmentation information of impurities are obtained using a mass spectrometer (ESI or APCI), enabling the identification of degradation products, synthesis intermediates, or by-products, meeting the requirements of ICH Q3B. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After acid digestion of the sample, AAS or inductively coupled plasma mass spectrometry (ICP-MS) is used to determine the levels of heavy metals such as lead, cadmium, mercury, and arsenic, ensuring compliance with pharmacopeia standards (e.g., ChP, USP). |
| Residual Solvents | Gas Chromatography (GC) | Residual organic solvents (e.g., ethanol, acetone, DMF) are separated using headspace or direct injection, with a DB-624 or PLOT column, and detected by FID. The method complies with ICH Q3C guidelines. |
| Appearance and Color | Visual Inspection + Color Measurement | The sample is observed as a white to off-white crystalline powder. If necessary, a colorimeter or colorimetric method (e.g., platinum-cobalt method) is used to quantify the yellowness index, ensuring consistency in appearance across batches. |
| Solubility | Solubility Test | Solubility is measured in common solvents such as water, ethanol, and acetone, serving as a reference for formulation development and quality control. Typically slightly soluble in water and readily soluble in alcohols. |
Technical Specifications of 2',3',4'-TRIHYDROXYACETOPHENONE
| Test Item | Specification |
|---|---|
| Appearance | Beige solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 148–152°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2',3',4'-TRIHYDROXYACETOPHENONE
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| Lot/Batch Number | *Required fields | |
NMR Spectra of 2',3',4'-TRIHYDROXYACETOPHENONE
Safety Information of 2',3',4'-TRIHYDROXYACETOPHENONE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2',3',4'-TRIHYDROXYACETOPHENONE
Industrial 2',3',4'-TRIHYDROXYACETOPHENONE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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