Coumarin-3-carboxylic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 531-81-7 |
| Product name | Coumarin-3-carboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Coumarin-3-carboxylic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Coumarin-3-carboxylic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Coumarin-3-carboxylic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Anticoagulant drug intermediate | Used as a precursor in the synthesis of coumarin-based anticoagulants (e.g., warfarin), with active pharmaceutical ingredients prepared via esterification, reduction, and related reactions |
| Organic Synthesis | Fluorescent probe and dye intermediate | Applied in synthesizing fluorescent compounds for fluorescent labeling and detection, with functional groups introduced via condensation or coupling reactions |
| Pesticides | Fungicide and plant growth regulator intermediate | Employed in synthesizing bioactive coumarin derivatives for agricultural chemical development |
| Materials Science | Functional polymer monomer | Used as a carboxyl-containing functional monomer in polymerization reactions to produce polymers with tailored optical properties |
Manufacturing Quality Control of Coumarin-3-carboxylic acid
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity Analysis | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 column with methanol-water or acetonitrile-water as the mobile phase, and UV detection (typically at 254 nm). Effectively separates coumarin-3-carboxylic acid from its impurities, providing accurate quantification. It is the standard method for purity determination. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Quantitative analysis of coumarin-3-carboxylic acid in samples is performed using external standard or internal standard methods by establishing a calibration curve. This method offers high sensitivity and reproducibility, widely applied in quality control of active pharmaceutical ingredients and formulations. |
| Structural Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | ¹H NMR and ¹³C NMR provide key structural information, such as carboxyl group signals, substitution patterns on the benzene ring, and characteristic signals of the coumarin core, enabling confirmation of correct molecular structure. |
| Molecular Weight Determination | Mass Spectrometry (MS, ESI-MS or LC-MS) | Electrospray ionization mass spectrometry (ESI-MS) or liquid chromatography-mass spectrometry (LC-MS) is used to detect the molecular ion peak ([M+H]⁺), confirming the molecular weight (theoretical value: 160.13), supporting structural identification and impurity profiling. |
| Residual Solvent Testing | Gas Chromatography (GC) | Utilizes headspace or direct injection with capillary columns to separate residual organic solvents (e.g., ethanol, acetone, dichloromethane). Complies with ICH Q3A/Q3C guidelines, ensuring process safety. |
| Residual Heavy Metal Testing | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Enables trace-level detection of heavy metals such as lead, cadmium, mercury, and arsenic in samples, meeting pharmaceutical heavy metal limits and ensuring product safety. |
| Water Content Determination | Karl Fischer Titration | A specific method for determining water content in samples, suitable for hygroscopic or hydrate-containing coumarin-3-carboxylic acid. Delivers precise results and is commonly used for moisture control in raw materials. |
| Melting Point Determination | Micro Melting Point Apparatus | Determines the temperature range during sample melting, offering a preliminary assessment of purity and physical properties, serving as an auxiliary identification method. |
Technical Specifications of Coumarin-3-carboxylic acid
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow powder or crystals |
| Purity | >=98.0% (LC-MS) |
| Melting Point | 194–197 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Coumarin-3-carboxylic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Coumarin-3-carboxylic acid
Packaging of Coumarin-3-carboxylic acid
Industrial Coumarin-3-carboxylic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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