6-Chloronicotinic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 5326-23-8 |
| Product name | 6-Chloronicotinic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 6-Chloronicotinic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 6-Chloronicotinic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 6-Chloronicotinic acid
| Industry | Application | Process |
|---|---|---|
| Pesticides | Key intermediate in the synthesis of the herbicide nicosulfuron | Nicosulfuron is produced via condensation of 6-chloronicotinic acid with amine compounds, followed by sulfonylurea formation |
| Pharmaceuticals | Intermediate for synthesizing antiviral, antitumor, and neuroactive drugs | Functions as a heterocyclic carboxylic acid in amidation, esterification, or coupling reactions to construct active molecular scaffolds |
| Chemical Synthesis | Organic building block for constructing nitrogen-containing heterocyclic compounds | Introduces functional groups via nucleophilic substitution or metal-catalyzed coupling reactions (e.g., Suzuki, Buchwald–Hartwig) |
| Materials Science | Building block for ligands or functional material precursors | Coordinates with metal ions to form complexes used in catalysis or optoelectronic material development |
Manufacturing Quality Control of 6-Chloronicotinic acid
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | Uses a C18 reversed-phase column with methanol-water or buffer salts (e.g., phosphate) as the mobile phase. Detection is performed at around 254 nm using a UV detector. Quantification is achieved by external standard method to accurately determine the content of 6-chloronicotinic acid. |
| Purity and Impurity Analysis | High-Performance Liquid Chromatography (HPLC) | Same as above; identifies the main peak and impurity peaks by retention time, calculates the area percentage of each impurity peak, and evaluates sample purity and related substances. |
| Structural Confirmation | Fourier Transform Infrared Spectroscopy (FTIR) | Records the infrared absorption spectrum of the sample and compares it with reference spectra to confirm the presence of functional groups such as carboxyl, pyridine ring, and C-Cl bond. |
| Polymorph Analysis | X-Ray Powder Diffraction (XRD) | Analyzes the crystal structure of solid samples to identify different polymorphic forms, ensuring batch-to-batch consistency (applicable for solid dosage form raw materials). |
| Moisture Content | Karl Fischer Titration | Determines moisture content precisely via electrochemical titration, suitable for quality control where moisture sensitivity is critical. |
| Residual Solvent Testing | Gas Chromatography (GC) | Employs polar or mid-polar capillary columns to detect organic solvents possibly remaining from manufacturing (e.g., methanol, ethanol, acetone), ensuring compliance with pharmacopeial limits for residual solvents. |
| Melting Point Determination | Melting Point Apparatus | Measures the melting temperature using an automatic or capillary melting point apparatus, used for preliminary identification and purity assessment (pure compounds exhibit sharp melting points). |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, determines levels of heavy metal elements such as lead, cadmium, mercury, and arsenic to ensure compliance with pharmaceutical or export standards. |
| Sulfated Ash (Residue on Ignition) | Gravimetric Method | The sample is treated with sulfuric acid and then ignited at high temperature. The weight of the residual inorganic matter is measured to assess the total inorganic impurity content. |
| Acid-Base Titration | Acid-Base Titration | Exploits the carboxylic acid group of 6-chloronicotinic acid, titrating with standardized NaOH solution to indirectly determine its content; suitable for rapid, preliminary testing. |
Technical Specifications of 6-Chloronicotinic acid
| Test Item | Specification |
|---|---|
| Appearance | White to yellow to orange crystalline powder |
| Purity | >=98.0% (by LC-MS) |
| Melting Point | 158–162°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 6-Chloronicotinic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 6-Chloronicotinic acid
Packaging of 6-Chloronicotinic acid
Industrial 6-Chloronicotinic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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