4-BROMOBUTYRONITRILE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 5332-06-9 |
| Product name | 4-BROMOBUTYRONITRILE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeIndustrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-BROMOBUTYRONITRILE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-BROMOBUTYRONITRILE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-BROMOBUTYRONITRILE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key intermediate for synthesizing antitumor agents (e.g., imatinib analogues) and sedatives (e.g., bromobutynitrile derivatives) | Undergoes nucleophilic substitution with amines to prepare 4-aminobutyronitrile derivatives; or participates in multi-step reactions—including reduction and cyclization—to construct nitrogen-containing heterocycles |
| Agrochemical Intermediates | Used to synthesize novel insecticides and plant growth regulators (e.g., pyrethroid derivatives containing the bromobutynitrile scaffold) | Reacts with thiols, phenols, or heterocyclic compounds via substitution or addition to introduce active functional groups that enhance biological activity |
| Organic Synthesis | Functions as a C4 chain-extension reagent and versatile synthon for constructing γ-substituted nitriles and cyclic compounds (e.g., tetrahydroisoquinolines, pyrrolidinones) | Reacts with Grignard reagents or organolithium reagents under basic conditions; or is catalytically reduced to 4-bromobutanal using NaBH₄/CuI, followed by participation in Wittig or condensation reactions |
| Materials Science | Used to prepare brominated functional monomers for synthesizing flame-retardant polyacrylates or brominated polymer additives | Undergoes esterification or click chemistry (e.g., CuAAC) coupling with unsaturated alcohols such as 2-hydroxyethyl acrylate to introduce polymerizable brominated side chains |
Manufacturing Quality Control of 4-BROMOBUTYRONITRILE
| Milestone | Common Testing Methods | Method Overview |
|---|---|---|
| Purity | Gas Chromatography (GC) | Separate the sample using a capillary column (e.g., DB-5 or HP-5), and quantitate the main component content using a FID detector. The purity is calculated by internal standard method or external standard method, which can detect impurities such as unreacted raw materials and by-products. |
| Moisture Content | Karl Fischer Titration | Quantitatively determine the trace water content in the sample by using a reaction between iodine, sulfur dioxide, pyridine, and methanol. It is suitable for precise determination of water content in 4-bromobutyronitrile (typically required <0.1%). |
| Residual Solvents | Gas Chromatography-Mass Spectrometry (GC-MS) | Use headspace injection or direct injection to separate solvent residues (such as ethanol, acetone, acetonitrile) by GC, and use MS for qualitative and quantitative analysis, complying with ICH Q3C standards. |
| Bromine Content | Combustion-Ion Chromatography / Oxygen Bomb Combustion + Ion Chromatography | The sample is combusted at high temperature to convert into bromide ions, which are then determined by ion chromatography. This method is used to verify whether the bromine content in the molecule conforms to the theoretical value (theoretical Br content about 58.7%). |
| Appearance and Color | Visual Inspection + Colorimetry | Observe that the sample is a colorless to slightly yellow transparent liquid. If necessary, use a platinum-cobalt colorimeter (APHA color) to quantitatively measure the color, keeping it within ≤10 Hazen units. |
| Boiling Point/Distillation Range | Distillation Method / Boiling Point Apparatus | Use a precision distillation device to determine the boiling point range (theoretical boiling point about 162–164°C), to check for high or low boiling point impurities. |
| Acid Value/Free Acid | Acid-Base Titration | Titrate the trace HBr or organic acid impurities in the sample with a standard sodium hydroxide solution, controlling the acid value ≤0.1 mg KOH/g. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine the heavy metal residues (Pb, Cd, Hg, As, etc.) in the sample after digestion, using AAS or ICP-MS, which comply with pharmacopoeia or ICH Q3D limit requirements (e.g., ≤10 ppm). |
| Chloride Impurities | Ion Chromatography (IC) or Silver Nitrate Titration | Detect Cl⁻ content by ion chromatography after hydrolysis or extraction of the sample, or determine chloride impurities by AgNO₃ titration method, ensuring no halogen cross-contamination. |
| Stability (Degradation Products) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column and UV detector (210–230 nm) to monitor possible hydrolysis products (such as 4-hydroxybutyronitrile, 4-aminobutyronitrile) or oxidation products, to evaluate storage stability. |
Technical Specifications of 4-BROMOBUTYRONITRILE
| Test Item | Specification |
|---|---|
| Appearance | Colorless to light yellow clear liquid |
| Purity | >=98.0% (GC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Refractive Index (n20/D) | 1.465–1.475 |
| Relative Density (20°C/25°C) | 1.220–1.240 g/cm³ |
| Odor | Characteristic pungent odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-BROMOBUTYRONITRILE
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NMR Spectra of 4-BROMOBUTYRONITRILE
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Industrial 4-BROMOBUTYRONITRILE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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