Boc-N-methyl-L-leucine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 53363-89-6 |
| Product name | Boc-N-methyl-L-leucine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Boc-N-methyl-L-leucine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Boc-N-methyl-L-leucine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Boc-N-methyl-L-leucine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Peptide Drug Synthesis | Used as an N-methylated amino acid monomer in solid-phase peptide synthesis (SPPS) to construct peptide drug chains containing N-methyl-L-leucine residues. |
| Pharmaceutical Industry | API Intermediate Production | Serves as a key structural building block for synthesizing active pharmaceutical ingredients (APIs) with defined stereochemistry, particularly to enhance metabolic stability. |
| Pharmaceutical Industry | N-Methylated Peptide Drug Development | Applied in the synthesis of N-methylated peptide drugs exhibiting high metabolic stability and improved oral bioavailability, including analogues of cyclic peptides such as cyclosporine. |
| Scientific Research | Peptide Modification and Labeling | Employed in laboratory-scale studies of peptide structural modification, where incorporation of N-methylleucine alters physicochemical properties—such as solubility and proteolytic resistance. |
Manufacturing Quality Control of Boc-N-methyl-L-leucine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 210 nm. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess determination using a chiral stationary phase with UV detection, resolving L- and D-enantiomers. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., ethyl acetate, toluene) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of iodine with water in pyridine/methanol medium. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pb, Cd, Hg, As) after acid digestion using inductively coupled plasma mass spectrometry. |
| Residual Palladium | ICP-OES | Quantification of palladium catalyst residue after microwave-assisted acid digestion using inductively coupled plasma optical emission spectrometry. |
| Acid Value | Acid-Base Titration | Neutralization of free carboxylic acid groups with standardized NaOH solution using phenolphthalein indicator. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using a polarimeter at 20 degC with sodium D-line (589 nm) in specified solvent (e.g., 1M HCl). |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution by measuring angular variation in laser light scattering intensity. |
| Loss on Drying | Gravimetric Analysis | Mass loss measured after drying sample at 105 degC under vacuum for 2 hours, expressed as weight percent. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., deprotected, di-Boc, hydrolyzed forms) using gradient reversed-phase HPLC. |
| Microbial Contamination | Membrane Filtration | Enumeration of aerobic mesophilic microorganisms by filtration, membrane transfer to culture media, and colony counting after incubation. |
Technical Specifications of Boc-N-methyl-L-leucine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 72~76°C |
| Optical Rotation | -30.0 to -24.0 deg (c=1, in CHCl3) |
| Identification (NMR) | Conforms to structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Boc-N-methyl-L-leucine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Boc-N-methyl-L-leucine
Packaging of Boc-N-methyl-L-leucine
Industrial Boc-N-methyl-L-leucine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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