4-Bromo-3-nitroanisole Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 5344-78-5 |
| Product name | 4-Bromo-3-nitroanisole |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Bromo-3-nitroanisole
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Bromo-3-nitroanisole Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Bromo-3-nitroanisole
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key intermediate for synthesizing antitumor agents (e.g., bendamustine derivatives) | Multi-step reaction involving nitration, bromination, and methylation; or bromination of 3-nitroanisole as the starting material |
| Pesticide Intermediates | Precursor for heterocyclic compounds used in synthesizing novel insecticides and fungicides | Substitution or coupling reactions with nitrogen-containing heterocyclic reagents (e.g., imidazole, triazole) to construct the active molecular scaffold |
| Dyes & Pigments | Diazotization component for modifying azo dyes and disperse dyes | Diazotized followed by coupling with aromatic amines or phenols; bromo- and nitro-substituents fine-tune hue and fastness properties |
| Organic Synthesis | Aryl halide substrate for cross-coupling reactions such as Suzuki and Heck | Carbon–carbon bond formation with boronic acids, alkenes, etc., catalyzed by palladium |
Manufacturing Quality Control of 4-Bromo-3-nitroanisole
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical state (e.g., white to off-white crystalline powder) and visible impurities with the naked eye to determine compliance with specified requirements. |
| Melting Point | Capillary Melting Point Determination | Place the sample into a capillary tube and slowly heat it using a melting point apparatus or Thiele tube setup. Record the initial and final melting temperatures to verify purity and consistency (typical melting range: approximately 78–82 °C). |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with a mobile phase of methanol-water or acetonitrile-water, and detect with UV detector (e.g., 254 nm). Quantify the main component using external standard method or area normalization method; typically requires ≥98.0%. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Similar conditions to content determination, but focused on separating and quantifying potential organic impurities (e.g., unreacted starting materials, by-products). Set limits for impurities (e.g., individual impurity ≤0.5%, total impurities ≤1.0%). |
| Water Content | Karl Fischer Titration | Utilize Karl Fischer reagent to react quantitatively with water in the sample, determining moisture content via potentiometric or coulometric titration. Controls product dryness (typically requires ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Use headspace injection or direct injection with FID detection. Analyze for residual organic solvents (e.g., methanol, dichloromethane) from synthesis according to ICH Q3C guidelines, ensuring compliance with specified limits. |
| Residue on Ignition / Ash Content | Gravimetric Method | Ignite the sample at high temperature until constant weight, then weigh the residual inorganic matter to assess inorganic impurity levels (typically requires ≤0.1%). |
| pH Value (if applicable) | pH Meter Method | Dissolve or suspend the sample in water at a defined concentration, then measure acidity or alkalinity using a calibrated pH meter. Used to assist in assessing degradation or impurity levels (may not be mandatory in some specifications). |
Technical Specifications of 4-Bromo-3-nitroanisole
| Test Item | Specification |
|---|---|
| Appearance | Yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 45-49°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Bromo-3-nitroanisole
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Bromo-3-nitroanisole
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Industrial 4-Bromo-3-nitroanisole Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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