PROTAMINE SULFATE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 53597-25-4 |
| Product name | PROTAMINE SULFATE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for PROTAMINE SULFATE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk PROTAMINE SULFATE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of PROTAMINE SULFATE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Long-term stabilization of insulin formulations | Serves as a critical excipient in long-acting insulin preparations (e.g., protamine zinc insulin), forming complexes with insulin; upon subcutaneous injection, reduced solubility delays insulin release and absorption, thereby extending pharmacological effect. |
| Pharmaceuticals | Drug carrier and delivery system | Leverages its cationic nature to form polyelectrolyte complexes with anionic macromolecules (e.g., heparin or DNA) via electrostatic interaction, enabling preparation of sustained-release microspheres or nanoparticles for protein- or peptide-based therapeutics. |
| Pharmaceuticals | Heparin antagonist | Neutralizes excess systemic heparin (an anticoagulant) by forming stable complexes that abolish its anticoagulant activity; commonly used for hemostasis management following cardiac surgery. |
| Biopharmaceuticals | Cell culture supplement | Added to culture media for specific cell types (e.g., primary hepatocytes, certain stem cells) to maintain cellular phenotype or promote cell adhesion and growth. |
| Medical Devices | Antithrombotic coating material | Exploits its heparin-binding capacity to formulate antithrombotic coatings on cardiovascular interventional devices (e.g., catheters, stents); immobilized heparin enhances blood compatibility. |
Manufacturing Quality Control of PROTAMINE SULFATE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Potency) | Acid-Base Titration | Quantifies total basic amino groups via titration with standardized HCl using methyl orange indicator. |
| Loss on Drying | Gravimetric Analysis | Measures weight loss after drying at 105 C for 2 h to determine volatile content and moisture. |
| Residue on Ignition | Gravimetric Analysis | Determines inorganic ash content by ignition at 600 C followed by weighing of residual residue. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) | Quantifies Pb, Cd, Hg, and As by atomization and absorption measurement at element-specific wavelengths. |
| Sulfate Content | Barium Sulfate Gravimetry | Precipitates sulfate as BaSO4 and determines mass after filtration and drying. |
| Protein Purity | UV-Vis Spectrophotometry | Estimates purity based on absorbance ratio A280/A260 to assess nucleic acid contamination. |
| pH (1% w/v solution) | Potentiometric pH Measurement | Measures hydrogen ion activity using calibrated glass electrode in aqueous solution. |
| Specific Optical Rotation | Polarimetry | Determines enantiomeric composition by measuring rotation of plane-polarized light at 589 nm. |
| Microbial Limits | Membrane Filtration and Plate Count | Quantifies aerobic mesophilic microorganisms using nutrient agar and incubation at 30-35 C for 3-5 days. |
| Endotoxin Level | Limulus Amebocyte Lysate (LAL) Assay | Detects bacterial endotoxins via enzymatic clotting reaction triggered by endotoxin in lysate. |
| Related Substances | Reverse-Phase HPLC | Separates and quantifies impurities using C18 column, UV detection at 214 nm, and gradient elution. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration with iodine-based reagent. |
Technical Specifications of PROTAMINE SULFATE
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.5% |
| Optical Rotation | -45° to -55° (c=1, in 1M HCl) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of PROTAMINE SULFATE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of PROTAMINE SULFATE
Industrial PROTAMINE SULFATE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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