4-Hydroxypiperidine hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 5382-17-2 |
| Product name | 4-Hydroxypiperidine hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Hydroxypiperidine hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Hydroxypiperidine hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Hydroxypiperidine hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of antipsychotics (e.g., paliperidone), antihistamines, and central nervous system agents | Used as a chiral building block in multistep organic synthesis, commonly incorporated into target molecular frameworks via N-alkylation, acylation, or coupling reactions |
| Pharmaceuticals | Preparation of selective 5-HT2A receptor antagonists and dopamine D2 receptor modulators | Reaction selectivity of the hydroxyl and nitrogen groups is controlled through protection/deprotection strategies, followed by substitution or condensation under solid-phase or solution-phase conditions |
| Agrochemicals | Nitrogen-containing heterocyclic structural unit for synthesizing novel insecticides and plant growth regulators | Introduced as the piperidine core into active molecules; functionalized side chains are constructed via derivatization reactions such as chlorination or cyanoethylation |
| Materials Science | Functional polymer monomer for producing heat-resistant polyamides or ion-exchange resins | Condensed with dicarboxylic acids or diisocyanates, or modified via epoxy ring-opening grafting to introduce hydrophilic or basic sites |
Manufacturing Quality Control of 4-Hydroxypiperidine hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Acid-Base Titration | Quantifies 4-hydroxypiperidine hydrochloride by titration with standardized NaOH using phenolphthalein indicator; based on neutralization of HCl salt. |
| Water Content | Karl Fischer Titration | Measures water via coulometric or volumetric reaction between water and iodine in a methanol-based reagent. |
| Residual Solvents | Gas Chromatography (GC) | Separates and quantifies volatile organic solvents (e.g., ethanol, acetone) using a capillary column and FID detection. |
| Heavy Metals | ICP-OES | Determines total elemental impurities (Pb, Cd, As, Hg, etc.) by plasma excitation and atomic emission spectroscopy. |
| Chloride Impurity | Potentiometric Titration | Detects excess chloride ions using silver nitrate titrant and Ag/AgCl electrode; endpoint determined by potential change. |
| Related Substances | HPLC-UV | Separates and quantifies structurally related impurities using reversed-phase C18 column and UV detection at 210 nm. |
| Melting Point | Capillary Melting Point Apparatus | Measures temperature range at which solid transitions to liquid, indicating purity and identity consistency. |
| Specific Optical Rotation | Polarimetry | Determines chiral purity and identity by measuring rotation of plane-polarized light in solution at specified concentration and wavelength. |
| pH (1% aqueous solution) | pH Meter | Measures hydrogen ion activity in a standardized aqueous solution to assess acid strength and hydrolytic stability. |
| Loss on Drying | Gravimetric Method | Determines volatile content by weight loss after drying at 105 C for 2 hours under controlled conditions. |
| Residue on Ignition | Sulfated Ash Method | Measures non-volatile inorganic residue after high-temperature ignition (700–800 C) in presence of sulfuric acid. |
| Microbial Limits | Membrane Filtration | Quantifies aerobic microorganisms and detects absence of specified pathogens (E. coli, Salmonella) per pharmacopeial guidelines. |
Technical Specifications of 4-Hydroxypiperidine hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 210-215°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Hydroxypiperidine hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Hydroxypiperidine hydrochloride
Safety Information of 4-Hydroxypiperidine hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Hydroxypiperidine hydrochloride
Industrial 4-Hydroxypiperidine hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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