5-Nitroindazole Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 5401-94-5 |
| Product name | 5-Nitroindazole |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Material GradeSpecialty GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Nitroindazole
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Nitroindazole Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Nitroindazole
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a pharmaceutical intermediate in the synthesis of antitumor or antimicrobial compounds | Organic synthesis, catalytic reactions |
| Research Institutions | Used as a biochemical reagent for kinase inhibition or cell signaling pathway studies | Laboratory-scale synthesis and purification |
| Materials Science | Used as a precursor for energetic materials or coordination compounds | Nitration, crystallization and separation |
Manufacturing Quality Control of 5-Nitroindazole
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity Determination | High-Performance Liquid Chromatography (HPLC) | Utilizes a C18 column with water-methanol or acetonitrile gradient elution, detected by a UV detector (254 nm or 280 nm). Purity of the main component is calculated via peak area normalization, effectively separating impurities and degradation products. |
| Content Determination | HPLC-UV / HPLC-MS | Quantitative analysis of 5-nitroindazole using external standard or internal standard methods. HPLC-MS enhances selectivity and sensitivity, making it suitable for precise determination of trace components, especially in complex matrices. |
| Impurity Profile Analysis | HPLC-MS/MS or LC-MS | Employs mass spectrometry coupling to identify structure-related impurities (e.g., nitro-reduction products, dimers, unreacted starting materials). Structural confirmation is achieved through fragment ion spectra, in compliance with ICH Q3B guidelines. |
| Residual Solvent Detection | Gas Chromatography (GC) | Uses headspace or direct injection with a FID detector to quantify residual solvents (e.g., DMF, ethanol, ethyl acetate) according to ICH Q3C standards, ensuring compliance with pharmaceutical-grade requirements. |
| Water Content Determination | Karl Fischer Titration (KF) | Determines trace water content in solid active pharmaceutical ingredients via electrochemical titration, ensuring stability and safe storage. |
| Melting Point Determination | Melting Point Instrument Method | Measures the melting point range of 5-nitroindazole (literature value: approximately 135–138°C) using a digital melting point apparatus, serving as a physical characteristic identifier and auxiliary purity indicator. |
| UV-Visible Absorption Spectroscopy | UV-Vis Spectrophotometry | Measures the maximum absorption wavelength (typically 260–290 nm) in methanol or acetonitrile for preliminary identification and approximate concentration estimation (requires calibration curve). Due to low specificity, it is commonly used as an auxiliary method. |
| Crystal Form Analysis | X-ray Powder Diffraction (XRPD) | Confirms consistency of the crystal form of 5-nitroindazole to avoid polymorphism-related impacts on solubility and bioavailability, applicable for quality control during formulation development. |
| Heavy Metal Residue Detection | ICP-MS or ICP-OES | Detects heavy metal elements such as lead, cadmium, mercury, and arsenic using inductively coupled plasma mass spectrometry or optical emission spectrometry, complying with limits specified in pharmacopeias (e.g., USP <232>, EP 2.5.10). |
| Chloride/Ionic Inorganic Impurity Detection | Ionic Chromatography (IC) | Detects inorganic anions (e.g., Cl⁻, SO₄²⁻) potentially introduced during manufacturing to ensure process cleanliness and control inorganic impurities in active pharmaceutical ingredients. |
Technical Specifications of 5-Nitroindazole
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow powder |
| Purity | ≥99.0% |
| Sulfate | ≤0.5% |
| Loss on drying | ≤0.5% |
| Melting point | 204~211°C |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Nitroindazole
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Nitroindazole
Packaging of 5-Nitroindazole
Industrial 5-Nitroindazole Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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