6-Hydroxy-2(1H)-3,4-dihydroquinolinone Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 54197-66-9 |
| Product name | 6-Hydroxy-2(1H)-3,4-dihydroquinolinone |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeMaterial GradeSpecialty GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 6-Hydroxy-2(1H)-3,4-dihydroquinolinone Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
| Industry | Application | Process Description |
|---|---|---|
| Pharmaceuticals | Pharmaceutical intermediate | Used as a key intermediate in the synthesis of certain quinolone antibacterial agents to construct the quinolone ring system. |
| Chemical Research | Organic synthesis reagent | Applied in laboratory-scale synthesis of complex organic molecules, participating in catalytic coupling, cyclization, and other organic reactions. |
| Agricultural Chemicals | Pesticide synthesis intermediate | Used in the synthesis of bioactive quinolone-based pesticides or plant growth regulators. |
| Materials Science | Functional material synthesis | Serves as a ligand or structural building block in the synthesis of novel functional materials such as metal–organic frameworks (MOFs). |
| Biochemistry | Biologically active compound research | Applied in studying the biological activity of quinolone compounds, including antimicrobial, antiviral, and antitumor properties. |
Manufacturing Quality Control of 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity and Content Determination | High-Performance Liquid Chromatography (HPLC) | Uses a C18 column with water-methanol or acetonitrile as the mobile phase (often adjusted with 0.1% formic acid or phosphoric acid to control pH), detected by UV detector at wavelengths of 250–280 nm. Quantification is performed using external standard or internal standard methods, enabling simultaneous determination of the main component and related substances. |
| Related Substances (Impurities) Testing | HPLC-UV or HPLC-MS | Gradient elution programs are employed to separate degradation products, synthetic intermediates, and isomers. UV detection limit is approximately 0.05%. When impurity structures are unknown or have similar polarity, coupling with mass spectrometry (MS) enables structural identification and quantification. |
| Moisture Content | Karl Fischer Titration | Measures trace moisture in samples using coulometric or volumetric Karl Fischer methods, suitable for solid active pharmaceutical ingredients. Ensures moisture levels comply with pharmacopoeial specifications (typically ≤0.5% or per process requirements). |
| Melting Point | Melting Point Analyzer | Determines the melting range of pure compounds (literature-reported values around 180–190°C), used for preliminary identification and purity assessment; a narrow melting range (≤2°C) indicates high purity. |
| UV Absorption Characteristics | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Measures maximum absorption wavelength (λmax) in methanol or ethanol solutions, typically showing strong absorption at 260–275 nm, used for qualitative confirmation and establishing the foundation for quantitative analysis methods. |
| Solubility | Shake Flask Method / Colorimetry | Determines equilibrium solubility in various pH buffers (e.g., pH 1.2, 6.8, 7.4) and solvents (water, ethanol, DMSO), supporting formulation development and bioavailability assessment. |
| Polymorphic Analysis | X-Ray Powder Diffraction (XRPD) | Used to confirm consistency of the drug substance’s polymorphic form, preventing variability in stability and dissolution behavior due to multiple crystal forms. Applicable for quality control of solid dosage form raw materials. |
| Heavy Metals and Residual Solvents | ICP-MS / Gas Chromatography (GC) | ICP-MS is used for detecting heavy metals such as lead, cadmium, and mercury (in compliance with ICH Q3D); GC (e.g., headspace method) is applied to detect residual solvents used during synthesis (e.g., ethanol, acetone, dichloromethane) in accordance with ICH Q3C. |
| Infrared Spectral Identification | Fourier Transform Infrared Spectroscopy (FT-IR) | Compares characteristic functional group absorption peaks (e.g., 3200–3400 cm⁻¹ for phenolic OH stretching vibration, 1650 cm⁻¹ for carbonyl, 1580 cm⁻¹ for aromatic ring) with reference spectra for structural confirmation. |
| Content Uniformity (in Formulations) | HPLC Method | For formulated products, multiple tablets/units are dissolved and analyzed via HPLC to assess content uniformity per unit, meeting USP/EP criteria (e.g., RSD ≤ 5%) to ensure dose consistency. |
| Stability-Indicating Method | Accelerated Degradation Study + HPLC | Subjects samples to stress conditions (acid, base, oxidation, light, heat), monitoring degradation product formation via HPLC to establish a specific method for stability studies. |
Technical Specifications of 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
| Test Item | Specification |
|---|---|
| Appearance | White to off-white powder |
| Purity | ≥99.5% |
| Single impurity | ≤0.1% |
| Loss on drying | ≤1.0% |
| Melting point | 235~240°C |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
Safety Information of 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 6-Hydroxy-2(1H)-3,4-dihydroquinolinone
Industrial 6-Hydroxy-2(1H)-3,4-dihydroquinolinone Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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