N-Acetyl-L-thioproline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 54323-50-1 |
| Product name | N-Acetyl-L-thioproline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Acetyl-L-thioproline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Acetyl-L-thioproline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Acetyl-L-thioproline
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Thioproline derivative used as a key intermediate in the synthesis of peptide-based therapeutics and bioactive molecules with anti-inflammatory or antitumor activity | Pharmaceutical synthesis (solid-phase/liquid-phase peptide synthesis, chiral drug manufacturing) |
| Pharmaceutical R&D | Biochemical research tool for investigating the impact of thioamide bonds on protein structure and function, and for metabolic stability studies | Scientific experimentation (enzyme inhibition kinetics, structure–activity relationship studies) |
| Organic Synthesis | Chiral building block for constructing sulfur-containing heterocycles or incorporating specific thioamide scaffolds | Asymmetric synthesis, catalytic reactions |
| Chemical Testing | Chemical reference standard for qualitative identification and quantitative analysis of related substances | Chromatographic analysis (HPLC, LC-MS reference standard preparation) |
Manufacturing Quality Control of N-Acetyl-L-thioproline
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection and Physical Property Measurement | Observe sample color, state (white or off-white crystalline powder), solubility (freely soluble in water and methanol, slightly soluble in ethanol), etc., to ensure compliance with pharmacopoeial or internal company specifications. |
| Identification | Infrared Spectroscopy (IR) | Compare the IR spectrum of the sample with that of the reference standard; confirm consistent absorption peaks corresponding to characteristic functional groups (e.g., amide carbonyl, thioether, carboxyl groups) for structural confirmation. |
| Identification | High-Performance Liquid Chromatography (HPLC) | Use identical chromatographic conditions as the reference standard (e.g., C18 column, water-acetonitrile gradient elution); compare retention times for consistency to confirm identity. |
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Determine the peak area of the main component using external standard method or area normalization method; calculate the content of N-acetyl-L-thioproline (typically ≥98.0%), while excluding interference from impurities. |
| Impurity Profile Analysis | High-Performance Liquid Chromatography (HPLC) | Utilize gradient elution and low-wavelength detection (e.g., 210–220 nm) to detect and quantify relevant impurities (e.g., unreacted L-proline, acetic acid, deacetylated products), in accordance with ICH Q3B guidelines. |
| Moisture Content | Karl Fischer Titration | Determine trace moisture levels using coulometric or volumetric Karl Fischer method; control moisture content (typically ≤1.0%) to prevent hydrolysis or microbial growth. |
| Melting Point | Melting Point Determination by Melting Point Apparatus | Determine the melting range (literature value approximately 150–155°C) to assess crystalline purity; an abnormal melting point may indicate impurity contamination. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine levels of lead, cadmium, mercury, arsenic, and other heavy metals according to pharmacopoeial methods (e.g., USP/EP), ensuring they remain below specified limits (e.g., Pb ≤ 5 ppm). |
| Residual Solvents | Gas Chromatography (GC) | Use headspace injection or direct injection to detect organic solvents potentially remaining from manufacturing processes (e.g., ethanol, acetic acid, acetone), meeting ICH Q3C standards. |
| Optical Rotation | Measurement by Polarimeter | Prepare a solution at a specified concentration (e.g., 1% w/v in water), measure specific rotation at 20°C; verify stereochemical purity (L-configuration should yield negative values, e.g., [α]D²⁰ ≈ -10° to -15°). |
| Chloride, Sulfate | Ion Chromatography or Chemical Colorimetry | Detect inorganic anion impurities such as Cl⁻ and SO₄²⁻; ensure compliance with pharmaceutical-grade specifications (e.g., chloride ≤ 0.01%). |
| Microbial Limits | Microbial Counting and Control Organism Testing | Conducted according to Chinese Pharmacopoeia General Rules 1105/1106 to test total aerobic bacteria count, mold and yeast count, and presence of Escherichia coli; ensure sterility or compliance with non-sterile active pharmaceutical ingredient standards. |
Technical Specifications of N-Acetyl-L-thioproline
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.5% (by NMR) |
| Water Content (KF) | <=0.5% |
| Melting Point | 128-132°C |
| Optical Rotation | +28.0° to +32.0° (c=1, in 1M HCl) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Acetyl-L-thioproline
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| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Acetyl-L-thioproline
Packaging of N-Acetyl-L-thioproline
Industrial N-Acetyl-L-thioproline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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