China Factory Direct
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| CAS number | 5445-51-2 |
| Product name | 1,1-Cyclobutanedicarboxylic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key structural motif for synthesizing antiviral agents and protease inhibitors | Introduces a chiral cyclobutyl scaffold into active molecules; target compounds are constructed via esterification, amidation, and related reactions |
| Organic Synthesis | Cyclobutyl building block for designing monomers of novel functional materials | Prepares cyclobutyl-substituted conjugated polymer precursors through decarboxylation, halogenation, or metal-catalyzed cross-coupling reactions |
| Agrochemical R&D | Core structural motif with potential bioactivity for developing new insecticides | Derivatization enhances lipophilicity and target-binding affinity; currently at the laboratory research stage |
| Test Item | Common Testing Method | Method Overview |
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| Appearance | Visual Inspection | Observe the sample's color, physical state, and presence of visible impurities under natural light or standard lighting conditions. |
| Purity | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with a UV detector (e.g., 210 nm), employing gradient elution with water/organic solvents (e.g., methanol or acetonitrile). Quantify purity by calculating the main peak area. |
| Assay | Acid-Base Titration | Titrate with standardized sodium hydroxide solution, using phenolphthalein or potentiometric detection to determine the endpoint. Calculate carboxylic acid content based on the volume of alkali consumed. |
| Melting Point | Melting Point Apparatus | Determine the initial and final melting temperatures using an automatic or capillary melting point apparatus with slow heating rate; assess whether the melting range meets specifications. |
| Moisture Content | Karl Fischer Titration | Use a Karl Fischer titrator to measure moisture content in samples; suitable for trace water detection with high accuracy. |
| Residual Solvents | Gas Chromatography (GC) | Use polar or non-polar capillary columns with an FID detector to identify and quantify organic solvents possibly remaining from manufacturing (e.g., methanol, ethyl acetate). |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Similar to purity testing; identify and control organic impurities by comparing retention times and peak areas of the main peak and impurity peaks. |
| Infrared Spectroscopy (IR) Identification | Fourier Transform Infrared Spectroscopy (FT-IR) | Obtain IR absorption spectra by pressing pellets or using ATR method, then compare with reference spectra to confirm consistency of functional groups (e.g., carboxyl group, cyclobutane backbone). |
| Nuclear Magnetic Resonance (NMR) | ¹H-NMR and ¹³C-NMR | Used for structural confirmation; dissolve sample in deuterated solvent and analyze proton and carbon NMR signals to verify molecular structure. |
| Residue on Ignition | Gravimetric Method | Weigh the residue after high-temperature incineration of the sample to calculate the content of non-volatile inorganic impurities and evaluate inorganic contamination levels. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Digest the sample, then detect residual heavy metal elements (e.g., lead, cadmium, mercury) using AAS or Inductively Coupled Plasma Mass Spectrometry (ICP-MS). |
| Test Item | Specification |
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| Appearance | Yellow solid |
| Purity | >=98.0% |
| Melting Point | 142-146 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Acid Value (mg KOH/g) | 320-340 mg KOH/g |
| Identification (NMR) | Consistent with structure |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Danger |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.