CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 54450-84-9 |
| Product name | CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key chiral building block for synthesizing antiviral drugs (e.g., HCV NS5A inhibitors) | Optically pure derivatives are prepared via chiral resolution or asymmetric synthesis, then employed in coupling and cyclization reactions to construct core heterocyclic structures |
| Organic Synthesis | Multifunctional cyclobutane-based structural unit for constructing bioactive molecules containing a cyclobutyl group | Functional group transformations—including ester hydrolysis, amidation, and reduction—are applied to incorporate the unit into target molecular frameworks |
Manufacturing Quality Control of CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection. |
| Related Substances | HPLC-UV | Separation and detection of structurally similar impurities using gradient HPLC with UV monitoring at appropriate wavelength. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents based on retention time and peak area. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine water content via stoichiometric reaction. |
| Acid Value | Acid-Base Titration | Titration with standardized NaOH solution using phenolphthalein indicator to determine free carboxylic acid groups. |
| Heavy Metals | ICP-OES | Multi-element quantification of metal impurities after acid digestion by measuring atomic emission intensities in plasma. |
| Chloride Content | Ion Chromatography | Separation and conductivity detection of chloride anions in aqueous extract using anion-exchange column. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue remaining after high-temperature incineration to determine inorganic ash content. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid using calibrated capillary tube method. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light induced by chiral centers in solution at specified concentration and path length. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity pattern to calculate size distribution of solid particles in suspension. |
| pH of Aqueous Suspension | pH Meter | Measurement of hydrogen ion activity in a defined aqueous suspension using calibrated glass electrode pH meter. |
Technical Specifications of CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 75–79°C |
| Identification (NMR) | Consistent with structure |
| Odor | Characteristic, mild |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER
Safety Information of CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER
Industrial CYCLOBUTANE-1,1-DICARBOXYLIC ACID ETHYL ESTER Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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