3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 545445-44-1 |
| Product name | 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 545445-44-1
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 545445-44-1 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 545445-44-1
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Experimental antitumor agent (targeting the PI3K/AKT/mTOR signaling pathway) | In vitro cellular screening, pharmacodynamic evaluation in animal models, structure–activity relationship (SAR) studies |
| Pharmaceutical R&D | Chemical probe for investigating cell cycle regulation and apoptosis mechanisms | Kinase inhibition assay (e.g., selectivity profiling across PI3Kα/β/δ/γ isoforms), Western blot analysis of downstream protein phosphorylation levels |
Manufacturing Quality Control of 545445-44-1
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identity | Infrared Spectroscopy (IR) | Compare the infrared absorption spectrum of the sample with that of the reference or standard spectrum to confirm the presence of characteristic functional groups (e.g., amide, pyridone, morpholine). |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Use chemical shift, integration area, and coupling constants of hydrogen atoms to verify molecular structure features and confirm the identity of the target compound. | |
| High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) | Combine retention time and mass-to-charge ratio (m/z) to provide molecular weight and fragmentation information for structural confirmation. | |
| Assay | High-Performance Liquid Chromatography (HPLC-UV) | Use a reversed-phase column with a UV detector (typically at 220–280 nm wavelength) to quantify the main component content using external or internal standard methods. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC-DAD/UV) | Separate the main peak and potential impurities (e.g., synthetic by-products, degradation products) using a gradient elution program, and calculate impurity content using area normalization or correction factor method. |
| Ultra Performance Liquid Chromatography-High Resolution Mass Spectrometry (UPLC-HRMS) | Separate and identify trace impurities with high sensitivity, suitable for unknown impurity identification. | |
| Residual Solvents | Headspace-Gas Chromatography (HS-GC-FID) | Use headspace sampling and FID detection to analyze residual organic solvents (e.g., methanol, ethanol, dichloromethane, DMF), complying with ICH Q3C guidelines. |
| Drying Loss / Moisture | Karl Fischer Titration | Accurately determine the moisture content in the sample, suitable for moisture-sensitive active pharmaceutical ingredients. |
| Thermogravimetric Analysis (TGA) | Measure mass changes during heating to assess the total amount of volatile components (including water and solvents). | |
| Melting Point | Capillary Melting Point Method | Determine the melting temperature range as a physical constant for identification and purity assessment. |
| Elemental Impurities | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Detected catalyst residues (e.g., Pd, Ni) and other potentially toxic elemental impurities according to ICH Q3D guidelines. |
| Polymorphic Form (if applicable) | X-ray Powder Diffraction (XRPD) | If polymorphism exists, confirm the dominant crystalline form using XRPD patterns to ensure consistency in formulation performance. |
| pH Value (if it is a solution) | pH Meter Measurement | If prepared as a solution for formulation, control the pH range to ensure stability. |
Technical Specifications of 545445-44-1
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 545445-44-1
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 545445-44-1
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Industrial 545445-44-1 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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