1-Benzylazetidin-3-ol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 54881-13-9 |
| Product name | 1-Benzylazetidin-3-ol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Benzylazetidin-3-ol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Benzylazetidin-3-ol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Benzylazetidin-3-ol
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key Intermediate | Used in the synthesis of antihyperglycemic agents (e.g., repaglinide) and novel DPP-4 inhibitors. |
| Pharmaceutical Industry | Drug Building Block | Serves as a nitrogen-containing heterocyclic structural unit in the development of β-lactam antibiotics and other novel antibacterial or antiviral agents. |
| Organic Synthesis | Chiral Synthesis Reagent | Leverages the chiral potential of its azetidine scaffold (via resolution or asymmetric synthesis) to construct biologically active molecules with defined stereochemistry. |
| Chemical R&D | Bioisostere | Substitutes for piperidine or pyrrolidine rings during medicinal chemistry optimization to improve pharmacokinetic properties (e.g., solubility, metabolic stability). |
Manufacturing Quality Control of 1-Benzylazetidin-3-ol
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~200–220 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-MS | Separation and detection of structurally related impurities (e.g., 1-benzylazetidin-3-one, residual solvents, synthesis intermediates) via gradient chromatography with UV or mass-selective detection. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water content based on the stoichiometric reaction of iodine with water in anhydrous methanol/pyridine medium. |
| Residual Solvents | GC-FID or GC-MS | Headspace gas chromatographic separation and quantification of volatile organic solvents (e.g., toluene, THF, ethanol) using flame ionization or mass spectrometric detection. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pb, Cd, Ni, Pd) after acid digestion, leveraging high sensitivity and isotopic resolution. |
| Chloride Content | Ion Chromatography (IC) or Potentiometric Titration | Anion-specific separation and quantification of chloride ions (IC) or argentometric titration with AgNO₃ endpoint detection. |
| Optical Rotation | [α]D Measurement (Polarimetry) | Determination of specific optical rotation at 589 nm to confirm chiral integrity and absence of racemization. |
| Residue on Ignition | Gravimetric Analysis | Measurement of non-volatile inorganic residue after controlled ashing at 700–800 °C, indicating inorganic salt contaminants. |
| pH (10% w/v aqueous solution) | pH Meter | Electrochemical measurement of hydrogen ion activity in aqueous suspension to assess acidic/basic degradation products. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition analysis to verify crystalline identity and detect impurities affecting solid-state behavior. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting. |
| Organic Volatile Impurities (OVI) | GC-FID | Targeted quantification of ICH Q3C-listed Class 2/3 solvents using calibrated headspace-GC with FID detection. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution to ensure batch-to-batch consistency for downstream processing. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and detection of specified pathogens per pharmacopeial guidelines (e.g., USP <61>). |
Technical Specifications of 1-Benzylazetidin-3-ol
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Melting Point | 65-69°C |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Benzylazetidin-3-ol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Benzylazetidin-3-ol
Packaging of 1-Benzylazetidin-3-ol
Industrial 1-Benzylazetidin-3-ol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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