tert-Butyl L-prolinate hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 5497-76-7 |
| Product name | tert-Butyl L-prolinate hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-Butyl L-prolinate hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-Butyl L-prolinate hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-Butyl L-prolinate hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Chiral auxiliary and asymmetric synthesis intermediate for preparing antiviral agents (e.g., HIV protease inhibitors) and peptide-based therapeutics | Used as a chiral ligand or catalyst precursor in asymmetric catalytic reactions such as Suzuki coupling and aldol reactions; employed in amino acid protection/deprotection cycles during solid-phase peptide synthesis (SPPS) |
| Organic Synthesis | Amino acid protecting reagent providing reversible tert-butoxycarbonyl (Boc) protection | Introduced onto L-proline under basic conditions; the hydrochloride salt form facilitates crystallization, purification, and storage; Boc deprotection is subsequently achieved using trifluoroacetic acid (TFA) |
| Biochemical Research | Building block for proline-containing cyclic peptides, collagen-mimetic peptides, and enzyme inhibitor probes | Applied as a structurally rigid proline derivative in liquid-phase or solid-phase peptide chain elongation to enhance conformational rigidity and metabolic stability of target peptides |
Manufacturing Quality Control of tert-Butyl L-prolinate hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reverse-phase HPLC with UV detection at 200-220 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and detection of impurities (e.g., residual L-proline, di-tert-butyl dicarbonate, tert-butanol) using gradient HPLC-UV against qualified impurity standards. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine-based reagent to determine trace water content based on stoichiometric reaction with water. |
| Residual Solvents | GC-FID | Headspace or direct injection GC with flame ionization detection to quantify residual solvents (e.g., dichloromethane, methanol, ethyl acetate) per ICH Q3C guidelines. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and others after acid digestion, based on atomic emission intensity at characteristic wavelengths. |
| Chloride Content | Ion Chromatography | Separation and conductivity detection of chloride ions in aqueous solution after sample dissolution and filtration. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using a polarimeter at 20-25 C and sodium D-line (589 nm), confirming stereochemical integrity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as solid-to-liquid phase change under controlled heating rate; used for identity and purity screening. |
| Loss on Drying | Gravimetric (105 C, 2 h) | Mass loss measured after drying under specified temperature and time, indicating volatile content including residual solvents and moisture. |
| pH (1% w/v aqueous solution) | pH Meter | Measurement of hydrogen ion activity in a standardized aqueous suspension using calibrated pH electrode; reflects hydrochloride salt behavior. |
| Residual Catalyst (Pd) | ICP-MS | Ultra-trace quantification of palladium (if used in synthesis) after microwave digestion, based on isotopic mass spectrometry detection. |
| Microbial Limits | Membrane Filtration & Plate Count | Enumeration of aerobic microorganisms and absence testing for specified pathogens per USP <61> and <62>. |
Technical Specifications of tert-Butyl L-prolinate hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 132-136°C |
| Optical Rotation | -33.0 to -30.0° (c=1, in 1M HCl) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-Butyl L-prolinate hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of tert-Butyl L-prolinate hydrochloride
Safety Information of tert-Butyl L-prolinate hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of tert-Butyl L-prolinate hydrochloride
Industrial tert-Butyl L-prolinate hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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