(S)-1-Cbz-3-Aminopyrrolidine hydrochloride Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 550378-39-7 |
| Product name | (S)-1-Cbz-3-Aminopyrrolidine hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for (S)-1-Cbz-3-Aminopyrrolidine hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-1-Cbz-3-Aminopyrrolidine hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-1-Cbz-3-Aminopyrrolidine hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key chiral building block for synthesizing antiviral drugs (e.g., HCV NS3/4A protease inhibitors) | Used as a chiral amine source in coupling reactions; target molecular core structure is constructed via deprotection, acylation, and related steps |
| Pharmaceutical Intermediates | Pyrrolidine ring precursor for synthesizing selective 5-HT2C receptor agonists (e.g., lorcaserin analogues) used as anti-obesity agents | (S)-configured pyrrolidine scaffold is introduced via chirally induced cyclization or asymmetric reductive amination |
| Pharmaceutical Intermediates | Preparation of kinase inhibitors containing a 3-aminopyrrolidine motif (e.g., ROCK and ALK inhibitors) | After Cbz deprotection, undergoes condensation with carboxylic acid derivatives or participates in SNAr reactions to form C–N bonds |
Manufacturing Quality Control of (S)-1-Cbz-3-Aminopyrrolidine hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-230 nm, comparing peak area against a certified reference standard. |
| Enantiomeric Purity | Chiral HPLC | Separation of (R)- and (S)-enantiomers on a chiral stationary phase, with quantitation based on peak area ratio. |
| Loss on Drying | Gravimetric (Oven Drying) | Mass loss measured after drying sample at 105 C for 2 hours under controlled humidity conditions. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common organic solvents (e.g., methanol, ethyl acetate, toluene). |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and Ni after acid digestion, based on atomic emission intensity. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode; endpoint detected by potential change. |
| Water Content | Karl Fischer Coulometric Titration | Electrochemical generation of titrant to react stoichiometrically with water; quantitation via coulombs consumed. |
| pH of Aqueous Solution | pH Meter Measurement | Measurement of hydrogen ion activity in a 1% w/v aqueous suspension using calibrated pH electrode. |
| Particle Size Distribution | Laser Diffraction | Analysis of light scattering pattern from dispersed particles to determine volume-based size distribution. |
| Residue on Ignition | Gravimetric (Sulfated Ash) | Mass of inorganic residue after ignition at 700-800 C following sulfuric acid treatment. |
| Related Substances | HPLC-UV | Detection and quantitation of process-related impurities and degradation products using gradient reverse-phase HPLC. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic mesophilic microorganisms and detection of specified pathogens via filtration, incubation, and colony counting. |
Technical Specifications of (S)-1-Cbz-3-Aminopyrrolidine hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | +13.0 to +16.0 deg (c=1, in 1M HCl) |
| Melting Point | 178 to 182 °C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of (S)-1-Cbz-3-Aminopyrrolidine hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Safety Information of (S)-1-Cbz-3-Aminopyrrolidine hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (S)-1-Cbz-3-Aminopyrrolidine hydrochloride
Industrial (S)-1-Cbz-3-Aminopyrrolidine hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply