China Factory Direct
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| CAS number | 5557-83-5 |
| Product name | L-Alanine benzyl ester hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty GradeCosmetic GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used in the synthesis of antiviral agents (e.g., adefovir ester derivatives) and protective amino acid components for peptide-based drugs | Employed as the benzyloxycarbonyl (Cbz)-protected form of L-alanine in solid-phase peptide synthesis (SPPS); hydrochloride salt formation improves crystallinity and stability, facilitating purification and storage; subsequent hydrogenolysis removes the benzyl protecting group |
| Organic Synthesis | Serves as a chiral building block in asymmetric catalytic reactions to construct complex molecules containing α-amino acid motifs | Participates in Strecker reactions with aldehydes/ketones under basic conditions or acts as a nucleophile in alkylation/acylation reactions; the hydrochloride salt enhances solubility in polar solvents and improves reaction control |
| Personal Care Ingredients | Used to prepare amino acid derivatives with moisturizing, antioxidant, and skin barrier repair properties (e.g., alanine-based surfactants) | Converted via saponification or transesterification into mild amphoteric surfactants such as sodium N-acyl-L-alaninate; the hydrochloride precursor ensures protonation of the amino group during reaction to suppress side reactions |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (L-Alanine Benzyl Ester Hydrochloride) | Acid-Base Titration with NaOH | Quantifies active compound by neutralizing HCl salt with standardized NaOH using phenolphthalein endpoint. |
| Water Content | Karl Fischer Titration | Measures water via iodine-sulfur dioxide reaction in methanol-based reagent, electrochemically detecting endpoint. |
| Optical Rotation | Polarimetry | Determines specific rotation using sodium D-line light to confirm chiral purity and identity. |
| Residual Solvents | Gas Chromatography (GC) with FID | Separates and quantifies organic solvents (e.g., toluene, methanol) based on retention time and flame ionization response. |
| Heavy Metals | ICP-OES | Quantifies trace metals (Pb, Cd, Hg, As) after acid digestion by measuring element-specific atomic emission intensities. |
| Chloride Impurity | Potentiometric Titration with AgNO3 | Detects chloride ions via silver nitrate titration monitored by silver electrode potential change. |
| Related Substances | HPLC with UV Detection | Separates and quantifies impurities (e.g., L-alanine, benzyl alcohol, dipeptide byproducts) using reversed-phase C18 column and UV absorbance. |
| pH of 5% Aqueous Solution | pH Meter Measurement | Measures hydrogen ion activity in aqueous suspension to assess acidity from residual HCl or degradation. |
| Loss on Drying | Gravimetric Analysis at 105 C | Determines volatile content by weight loss after controlled heating under specified time and temperature. |
| Residue on Ignition | Sulfated Ash Gravimetry | Measures inorganic residue after high-temperature combustion following sulfuric acid treatment. |
| Microbial Contamination | Membrane Filtration and Plate Count | Detects aerobic microorganisms by filtration, membrane transfer to agar, and colony enumeration after incubation. |
| Particle Size Distribution | Laser Diffraction | Measures particle size range and distribution by analyzing angular scattering pattern of laser beam passing through dispersed sample. |
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 142-146°C |
| Optical Rotation | -9.0 to -11.0° (c=1, in 1M HCl) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.