N-Succinimidyl 3-maleimidopropionate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 55750-62-4 |
| Product name | N-Succinimidyl 3-maleimidopropionate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Succinimidyl 3-maleimidopropionate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Succinimidyl 3-maleimidopropionate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Succinimidyl 3-maleimidopropionate
| Industry | Application | Process |
|---|---|---|
| Biochemistry / Bioconjugation | Crosslinker between primary amines of proteins, peptides, or antibodies and thiol-containing molecules (e.g., cysteine) | In pH 6.5–8.5 buffer, the NHS ester reacts with primary amines to form stable amide bonds, while the maleimide group undergoes Michael addition with thiols to yield stable thioether bonds |
| Pharmaceutical R&D | Linker in antibody–drug conjugate (ADC) construction | Conjugates cytotoxic drugs to free cysteine residues on antibodies via the maleimide terminus for targeted delivery |
| Diagnostics Reagent Development | Conjugation of fluorescent probes or enzyme labels to target proteins | Thiol-modified reporter molecules (e.g., fluorescein, HRP) are first prepared, then coupled to target protein amines using this bifunctional reagent |
| Materials Science | Functionalization of nanoparticles or surface modification | After introducing primary amines onto nanoparticle surfaces, this heterobifunctional reagent bridges thiol-containing ligands or biomolecules |
| Proteomics | Preparation of immobilized enzymes or affinity purification media | Enzymes or ligands are immobilized onto amino-functionalized solid supports via the maleimide terminus for use in affinity chromatography or enzymatic reactors |
Manufacturing Quality Control of N-Succinimidyl 3-maleimidopropionate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification based on peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities using gradient reversed-phase HPLC with UV monitoring. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration measuring water via iodine-sulfur dioxide reaction in pyridine-methanol medium. |
| Acid Value | Acid-Base Titration | Neutralization of acidic functional groups with standardized NaOH solution using phenolphthalein indicator. |
| Free Maleimide Content | UV-Vis Spectrophotometry | Quantitation of unreacted maleimide group based on absorbance at ~250 nm, calibrated against maleic anhydride standard. |
| NHS Ester Hydrolysis Products | HPLC-UV | Detection and quantification of hydrolyzed by-products (e.g., 3-maleimidopropanoic acid and N-hydroxysuccinimide) via isocratic HPLC. |
| Heavy Metals | ICP-OES | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion using inductively coupled plasma optical emission spectrometry. |
| Residue on Ignition | Gravimetric Analysis | Measurement of inorganic ash content after high-temperature incineration at 600-700 C followed by weighing. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of solid material against established visual reference standards. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range over which the solid transitions to liquid using calibrated capillary method. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light at 20 C using sodium D-line (589 nm) to assess chiral purity and identity. |
Technical Specifications of N-Succinimidyl 3-maleimidopropionate
| Test Item | Specification |
|---|---|
| Appearance | Off-white to white solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 125–135°C |
| Identification (NMR) | Conforms to reference standard |
| Identification (IR) | Conforms to reference standard |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Succinimidyl 3-maleimidopropionate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Succinimidyl 3-maleimidopropionate
Safety Information of N-Succinimidyl 3-maleimidopropionate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-Succinimidyl 3-maleimidopropionate
Industrial N-Succinimidyl 3-maleimidopropionate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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