China Factory Direct
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| CAS number | 5586-73-2 |
| Product name | 3,3-Diphenylpropylamine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Organic synthesis intermediate | Used to prepare biologically active compounds; serves as an intermediate for structural modification of drug molecules |
| Chemical research | Research reagent | Applied in laboratories for synthesis of amine compounds and mechanistic studies |
| Milestone | Common Testing Methods | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Using a C18 chromatographic column, acetonitrile-water (with 0.1% formic acid or trifluoroacetic acid) as the mobile phase, and UV detection at 254 nm. Quantification is performed using external standard method or internal standard method to determine the content of the main component. It has high accuracy and is suitable for purity analysis. |
| Impurity Profile Analysis | High-Performance Liquid Chromatography (HPLC-UV/DAD) | Gradient elution program is used to separate structurally related impurities (such as monophenylpropanamine, oxidation products, unreacted raw materials, etc.). The DAD detector can obtain spectral data to confirm the structure of impurities, in compliance with ICH Q3B guidelines. |
| Residual Solvents | Gas Chromatography (GC-FID/MS) | Using headspace injection or direct injection, with DB-624 or HP-INNOWAX columns, FID detector quantifies residual solvents such as ethanol, acetone, dichloromethane, etc., in accordance with USP <467> or EP 5.4.2 standards. |
| Water Content | Karl Fischer Titration | The method uses an iodine-sulfur dioxide-pyridine-methanol system to react quantitatively with water. The water content is determined by coulometric or volumetric methods, suitable for moisture control in active pharmaceutical ingredients (typically ≤0.5%). |
| Melting Point | Melting Point Apparatus Method | Use a digital melting point apparatus to determine the melting range (literature value approximately 68–72°C), used for preliminary identification and purity assessment. An abnormal melting point may indicate the presence of impurities. |
| Optical Rotation (if chiral compound) | Refractometer and Polarimeter Method | If 3,3-diphenylpropanamine has a chiral center (in reality, it is a non-chiral molecule, so this item is usually not applicable). Optical purity can be detected, but since the compound has a symmetrical structure and no optical activity, it is generally not tested. |
| UV Absorption Characteristics | UV-Vis Spectrophotometry | Determine the maximum absorption wavelength (λmax ≈ 254 nm) in ethanol or methanol, used for auxiliary identification and concentration estimation, often as a supplementary verification for HPLC methods. |
| Chloride/Sulfate Impurities | Ion Chromatography (IC) or Colorimetry | Ion chromatography is used to detect inorganic anions (Cl⁻, SO₄²⁻), or colorimetric methods (e.g., silver nitrate for chloride) are used to control the level of inorganic impurities, in compliance with pharmacopoeia general chapter <251>. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, heavy metals such as lead, cadmium, mercury, and arsenic are determined by AAS or ICP-MS, in compliance with ICH Q3D guidelines, typically with limits ≤10 ppm. |
| pH Value (in aqueous solution) | pH Meter Method | Dissolve the sample in purified water (concentration about 1 mg/mL) and measure the pH value (usually weakly alkaline, pH 8–10), used to evaluate acidity/alkalinity and process stability. |
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Odor | Characteristic amine odor |
| Refractive Index (n20/D) | 1.575–1.585 |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.