Methyl 4-oxo-3-piperidinecarboxylate hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 56026-52-9 |
| Product name | Methyl 4-oxo-3-piperidinecarboxylate hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl 4-oxo-3-piperidinecarboxylate hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl 4-oxo-3-piperidinecarboxylate hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl 4-oxo-3-piperidinecarboxylate hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Synthesis | Intermediate for synthesizing piperidine-based pharmaceuticals | Used in organic synthesis and catalyzed condensation reactions |
| Drug Discovery | Building block for bioactive molecules containing a piperidine ring | Applied in multi-step functional group transformations and cyclization reactions |
| Chemical Reagents | Source of the piperidinone structural motif | Employed in standard organic synthesis operations |
Manufacturing Quality Control of Methyl 4-oxo-3-piperidinecarboxylate hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~210 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., 4-piperidone, methyl ester hydrolysis products) using gradient HPLC-UV with a validated stability-indicating method. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify residual methanol, dichloromethane, or toluene per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric electrochemical reaction. |
| Heavy Metals | ICP-MS | Quantification of elemental impurities (e.g., Pb, Cd, Ni, Fe) after acid digestion, per ICH Q3D, using inductively coupled plasma mass spectrometry for sub-ppb sensitivity. |
| Chloride (Cl⁻) Content | Potentiometric Titration | Direct titration with silver nitrate using a silver/silver chloride electrode to detect endpoint via potential change; measures free and ionic chloride from HCl salt. |
| pH (1% w/v aqueous solution) | pH Potentiometry | Measurement of hydrogen ion activity in a saturated aqueous suspension using calibrated pH electrode; reflects protonation state and residual acidity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition analysis by observing solid-to-liquid phase change under controlled heating; confirms identity and crystallinity. |
| Loss on Drying (LOD) | Gravimetric Thermogravimetry | Weight loss measured after drying at 105 °C under vacuum or nitrogen; assesses volatile content including residual solvents and moisture. |
| Specific Optical Rotation | [α]D | Polarimetric measurement at 589 nm (Na D-line) to confirm chiral integrity and absence of racemization during synthesis or storage. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample using Mie scattering theory to determine D10, D50, D90 values relevant to filtration and formulation performance. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per Ph. Eur. 2.6.12/USP <61>. |
Technical Specifications of Methyl 4-oxo-3-piperidinecarboxylate hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl 4-oxo-3-piperidinecarboxylate hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Safety Information of Methyl 4-oxo-3-piperidinecarboxylate hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Methyl 4-oxo-3-piperidinecarboxylate hydrochloride
Industrial Methyl 4-oxo-3-piperidinecarboxylate hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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