5-Fluoro-2-oxindole Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 56341-41-4 |
| Product name | 5-Fluoro-2-oxindole |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 5-Fluoro-2-oxindole
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Fluoro-2-oxindole Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Fluoro-2-oxindole
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Pharmaceutical intermediates (e.g., for anticancer drug synthesis) | Used in organic synthesis and coupling reactions |
| Agrochemicals | Precursors to active ingredients in insecticides or fungicides | Applied in structural modification and functional group transformation |
| Materials Science | Monomers for optoelectronic materials or polymers | Used in polymerization and molecular design |
| Research | Building blocks for bioactive molecules or probes | Applied in laboratory-scale synthesis and structural optimization |
Manufacturing Quality Control of 5-Fluoro-2-oxindole
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Characteristics | Visual Inspection + Physical Property Measurement | Observe color and state (usually white to off-white crystalline powder), measure melting point (literature value approximately 120–125°C), and confirm it meets pharmacopoeia or internal control standards. |
| Identification | Infrared Spectroscopy (IR) | Confirm structure by comparing characteristic absorption peaks in infrared spectra (e.g., C=O stretching ~1680 cm⁻¹, C-F stretching ~1200–1250 cm⁻¹) with standard spectra. |
| High-Performance Liquid Chromatography (HPLC) | Confirm the target compound using a standard reference substance by comparing retention time; commonly uses a C18 column with acetonitrile-water (containing 0.1% formic acid) as mobile phase. | |
| Nuclear Magnetic Resonance Spectroscopy (¹H/¹³C NMR) | Confirm the structure through characteristic chemical shifts in hydrogen and carbon spectra (e.g., C5-F substitution causes neighboring proton chemical shift changes); this is a high-confidence identification method. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Quantify using external or internal standard methods with UV detection (commonly at wavelengths of 220–254 nm), linear range 0.01–2.0 mg/mL, R² > 0.999. |
| High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) | Used for high-sensitivity quantification by detecting characteristic ion fragments (e.g., [M+H]⁺ m/z 152), suitable for trace impurities or low-content samples. | |
| Impurity Profile Analysis | HPLC (Gradient Elution) | Detect related substances (e.g., unreacted raw materials, defluorinated byproducts, oxidation products), using gradient elution for separation; impurity limits are typically ≤0.1% (single impurity) or ≤0.5% (total impurities). |
| Gas Chromatography-Mass Spectrometry (GC-MS) | Used for detecting volatile organic impurities (e.g., residual solvents: methanol, acetonitrile, DMF), complying with ICH Q3C standards. | |
| Residual Solvents | Gas Chromatography (GC) | Determine residual solvents using headspace sampling with DB-624 or HP-INNOWAX columns; detect ICH Class III solvents, meeting limit requirements (e.g., acetonitrile ≤410 ppm). |
| Moisture Content | Karl Fischer Titration (KF) | Determine moisture content via titration; usually requires ≤0.5% (w/w) to ensure stability and crystallinity. |
| Melting Point | Melting Point Apparatus | Determine using capillary or automatic melting point apparatus, compare with literature values (120–125°C), to assess purity and polymorphic consistency. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect heavy metals such as lead, cadmium, mercury, and arsenic based on ICH Q3D standards; total heavy metal limit is typically ≤10 ppm. |
| Particle Size Distribution (if applicable) | Laser Diffraction | For powder formulations or intermediates requiring controlled solubility, determine D50 particle size to ensure process consistency. |
| Chloride/Fluoride Residue | Ion Chromatography (IC) | Detect possible residual inorganic halides (e.g., Cl⁻, F⁻); fluoride can be detected using a dedicated fluoride electrode or IC; limit ≤100 ppm. |
Technical Specifications of 5-Fluoro-2-oxindole
| Test Item | Specification |
|---|---|
| Appearance | Brown solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148-152°C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 5-Fluoro-2-oxindole
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Fluoro-2-oxindole
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Industrial 5-Fluoro-2-oxindole Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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