4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 56447-54-2 |
| Product name | 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid
| Industry | Application | Process |
|---|---|---|
| Pesticides | Serves as a key intermediate in the synthesis of novel herbicides (e.g., flucetosulfuron) | Constructs the sulfonylurea herbicide core structure via multi-step reactions, including diazotization, sulfonyl chlorination, and hydrolysis |
| Pharmaceuticals | Used as a structural building block in the synthesis of antidiabetic agents (e.g., glimepiride derivatives) and protein kinase inhibitors | Introduces fluorine/chlorine/sulfonyl groups via amidation, cyclization, and chiral modification to optimize pharmacokinetic properties |
Manufacturing Quality Control of 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, calibrated against certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and peak area normalization. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common organic solvents (e.g., methanol, acetone, toluene) per ICH Q3C guidelines. |
| Moisture Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine water content by electrochemical endpoint detection. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and Cr after acid digestion, based on atomic emission intensity at characteristic wavelengths. |
| Chloride Ion Impurity | Ion Chromatography | Separation and quantification of Cl- using suppressed conductivity detection with anion-exchange column and carbonate eluent. |
| Sulfate Impurity | Ion Chromatography | Determination of SO4(2-) via ion chromatography with conductivity detection following sample dissolution and filtration. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement using calibrated capillary apparatus; onset and range recorded per USP <741>. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion using laser scattering to determine D10, D50, D90 values per ISO 13320. |
| pH of Aqueous Slurry | Potentiometric pH Measurement | Measurement of pH in a 1:10 w/v suspension in purified water using calibrated pH electrode. |
| Loss on Drying | Gravimetric Heating | Weight loss measured after drying at 105 C for 2 hours under vacuum or forced-air oven, per USP <731>. |
| Residual Catalyst (Pd) | ICP-MS | Ultra-trace quantification of palladium using inductively coupled plasma mass spectrometry after microwave-assisted acid digestion. |
Technical Specifications of 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 148–152°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid
Safety Information of 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid
Industrial 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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