tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 571188-59-5 |
| Product name | tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing kinase inhibitors (e.g., ALK and ROS1 inhibitors) | Used as a key intermediate to construct the drug molecule scaffold via acylation, coupling, or cyclization reactions |
| Pharmaceuticals | Precursor for antitumor drug synthesis | Applied as a piperazine-derived building block in multistep synthesis, participating in Suzuki coupling or Boc deprotection reactions |
| Pharmaceuticals | Construction of pyridine-piperazine-containing drug candidates | After Boc deprotection, reacted with carboxylic acids or sulfonyl chlorides to form active amine compounds |
Manufacturing Quality Control of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Reverse-phase C18 column is used, with a gradient elution of water-acetonitrile or methanol-buffer salt (e.g., phosphate) as the mobile phase. UV detection is performed at 254–280 nm. The main component content is calculated using area normalization or external standard method, ensuring it is not less than 98.0%. |
| Related Substances (Impurity Profile) | HPLC-UV or HPLC-MS | Same HPLC system is optimized to separate potential degradation products (e.g., de-tert-butyl product, oxides, dimers). Detection limit typically ≤0.1%. When necessary, mass spectrometry (MS) is employed for structural identification of impurities. |
| Residual Solvents | Gas Chromatography (GC) | Headspace or direct injection is used with DB-624 or HP-INNOWAX columns and FID detector. Common organic solvents such as methanol, ethanol, ethyl acetate, dichloromethane, and tetrahydrofuran are tested according to ICH Q3C guidelines, meeting specified limits. |
| Water Content | Karl Fischer Titration | Electrochemical or volumetric Karl Fischer reagent is used to accurately determine trace moisture in samples, controlled at ≤0.5% (based on dosage form requirements), preventing hydrolysis or crystallization abnormalities. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After sample digestion, levels of heavy metals including lead, cadmium, mercury, arsenic, and copper are measured, complying with ICH Q3D or pharmacopoeial standards (e.g., ≤10 ppm). |
| Melting Point | Melting Point Apparatus | Determined using capillary tube method or thermal analysis instrument; typical melting range is approximately 110–120°C, used for preliminary identification and batch-to-batch consistency assessment. |
| Infrared Spectroscopy (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Comparison of infrared absorption spectra between reference standard and test sample in the range of 4000–400 cm⁻¹ to confirm structural consistency of functional groups (e.g., amino, ester, pyridine ring). |
| Ultraviolet-Visible Absorption Spectroscopy (UV-Vis) | UV-Vis Spectrophotometer | Sample dissolved in methanol or acetonitrile; maximum absorption wavelength (λmax ≈ 265–275 nm) is determined for qualitative identification and auxiliary quantitative analysis. |
| Solubility | Shaking Flask Method / Visual Observation | Solubility assessed in different pH buffer solutions (e.g., pH 1.2, 4.5, 6.8) and water to evaluate physicochemical properties, supporting formulation development. |
| Chiral Purity (if applicable) | Chiral HPLC or SFC | If chiral centers exist (this compound has no chiral center, but may be introduced during synthesis), enantiomers are separated using chiral stationary phases (e.g., Chiralpak AD/AS), ensuring enantiomeric purity ≥99.5%. |
| pH Value (Solution) | pH Meter | 1% aqueous solution (or ethanol/water mixture) prepared and pH measured, controlled within the range of 5.0–7.5 to prevent degradation caused by excessive acidity or alkalinity. |
Technical Specifications of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
| Test Item | Specification |
|---|---|
| Appearance | Brown solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Safety Information of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
| Pictograms |   |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Industrial tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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