5-Amino-3-(trifluoromethyl)picolinonitrile Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 573762-62-6 |
| Product name | 5-Amino-3-(trifluoromethyl)picolinonitrile |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 5-Amino-3-(trifluoromethyl)picolinonitrile
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 5-Amino-3-(trifluoromethyl)picolinonitrile Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 5-Amino-3-(trifluoromethyl)picolinonitrile
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for anticancer drugs; used in the synthesis of kinase inhibitor candidates | Undergoes Suzuki coupling with haloarenes or cross-coupling with boronic acid derivatives |
| Agrochemicals | Key structural motif in novel insecticides and fungicides | Participates in cycloaddition reactions or serves as a heterocycle building block to introduce trifluoromethyl groups for enhanced metabolic stability |
| Materials Science | Precursor for functional materials in organic light-emitting diode (OLED) electron transport layers | Integrated into conjugated backbones via metal-catalyzed C–N coupling (e.g., Ullmann or Buchwald–Hartwig reactions) |
Manufacturing Quality Control of 5-Amino-3-(trifluoromethyl)picolinonitrile
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Active Pharmaceutical Ingredient (API) Content | High-Performance Liquid Chromatography (HPLC) | Utilizes a C18 reversed-phase column with gradient elution using water-acetonitrile or methanol. The main peak area is detected by UV detector (210–260 nm) and quantified via external or internal standard method. Suitable for high-precision content determination (typically ≥98%). |
| Impurity Profile Analysis | HPLC-UV / HPLC-MS | Employs gradient elution to separate degradation products, unreacted starting materials, and by-products (e.g., deaminated compounds, hydrolysis products). Impurity structures are identified through UV spectral comparison or mass spectrometry (ESI-MS), in compliance with ICH Q3B guidelines. |
| Cyano Group (–CN) Content Verification | Fourier Transform Infrared Spectroscopy (FT-IR) | Detects the characteristic –C≡N stretching vibration absorption of the cyano group in the range of 2200–2260 cm⁻¹ for qualitative confirmation of the presence of the cyano group, supporting structural identification. |
| Trifluoromethyl (–CF₃) Verification | ¹⁹F Nuclear Magnetic Resonance Spectroscopy (¹⁹F NMR) | Observes the characteristic singlet peak of –CF₃ in ¹⁹F NMR (e.g., 75 MHz) at δ ≈ –55 to –65 ppm, used to confirm structural integrity of the substituent and assess purity. |
| Amino Group (–NH₂) Confirmation | ¹H NMR / FT-IR | In ¹H NMR, amino protons appear as peaks in the range of δ 4.5–6.0 ppm (solvent-dependent); in FT-IR, N–H stretching vibrations are observed at 3300–3500 cm⁻¹, used for functional group verification. |
| Melting Point | Capillary Melting Point Apparatus | Determines the melting point range (typical value approximately 130–140°C; verify against literature values), used for preliminary purity assessment—impurities may lower the melting point or broaden the melting range. |
| Moisture Content | Karl Fischer Titration | Measures trace moisture content using coulometric or volumetric methods, ensuring moisture levels ≤0.5% to prevent hydrolysis and maintain stability and reaction efficiency in subsequent processes. |
| Residual Solvents | Gas Chromatography (GC-FID / GC-MS) | Detects residual organic solvents from synthesis (e.g., DMF, acetonitrile, methanol, dichloromethane), quantified according to ICH Q3C guidelines to ensure compliance with pharmaceutical standards. |
| Elemental Composition (C, H, N, F) | Elemental Analyzer (EA) | Measures C, H, and N content via combustion analysis; fluorine content can be determined indirectly using oxygen flask combustion followed by ion-selective electrode or ICP-MS. Results within ±0.3% of theoretical values are considered acceptable. |
| Solubility and Appearance | Visual Inspection + Solubility Test | Assesses color (should be white to off-white crystalline powder) and physical state; evaluates solubility behavior in common solvents (e.g., ethanol, acetone, DMF, water) as an auxiliary quality control parameter. |
| Heavy Metal Residues | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detects residual heavy metals such as Pb, Cd, Hg, As, Cu, meeting pharmacopeial limits (e.g., USP <231> or EP 2.5.10), typically ≤10 ppm. |
Technical Specifications of 5-Amino-3-(trifluoromethyl)picolinonitrile
| Test Item | Specification |
|---|---|
| Appearance | Light orange to yellow to green crystalline powder |
| Purity | >=98.5% (LC-MS) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 5-Amino-3-(trifluoromethyl)picolinonitrile
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 5-Amino-3-(trifluoromethyl)picolinonitrile
Safety Information of 5-Amino-3-(trifluoromethyl)picolinonitrile
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 5-Amino-3-(trifluoromethyl)picolinonitrile
Industrial 5-Amino-3-(trifluoromethyl)picolinonitrile Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply