(S)-(+)-Nipecotic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 59045-82-8 |
| Product name | (S)-(+)-Nipecotic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-(+)-Nipecotic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-(+)-Nipecotic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-(+)-Nipecotic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key chiral intermediate for synthesizing the antidepressant varenicline | Used to construct the drug’s core scaffold via coupling with specific heterocyclic compounds |
| Pharmaceutical Industry | Chiral building block for synthesizing the oral antidiabetic drug sitagliptin | Employed in asymmetric synthesis or as a chiral source to construct piperazine/pyrrolidine derivatives |
| Pharmaceutical Industry | API synthesis intermediate for preparing immunosuppressants | Serves as a precursor to lactams or carboxylic acid derivatives, enabling amide coupling or reductive amination reactions |
| Pharmaceutical Industry | New drug discovery: synthesis of diverse G protein-coupled receptor (GPCR) ligands | Leverages its rigid piperidine ring structure for scaffold hopping or structural modification to enhance pharmacological activity |
| Organic Synthesis | Chiral auxiliary or ligand | Applied in asymmetric catalytic reactions to induce stereoselectivity in product formation |
| Biochemistry | Building block for peptides and peptide mimetics | Incorporated to introduce a conformationally restricted piperidine ring, improving metabolic stability of peptides |
Manufacturing Quality Control of (S)-(+)-Nipecotic acid
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection + Physical Property Determination | Observe sample color and state (white or off-white crystalline powder), determine melting point range (literature value approximately 150–155 °C), in compliance with pharmacopoeial or internal company specifications. |
| Identification | Infrared Spectroscopy (IR) | Compare characteristic IR absorption peaks (e.g., carboxyl C=O stretching vibration ~1710 cm⁻¹, N–H bending vibration ~1550 cm⁻¹) with reference spectra to confirm molecular structure. |
| High-Performance Liquid Chromatography (HPLC) | Use a chiral column (e.g., Chiralpak AD-H or OD-H) to separate enantiomers; retention time matches that of the standard, confirming the (S)-configuration. | |
| Optical Rotation Measurement | Measure specific optical rotation [α]₂₀ᴰ in a specified solvent (e.g., water or methanol), typical value approximately -10° to -15°, compared with theoretical values to confirm optical purity. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a non-chiral C18 column with UV detection (210–220 nm); quantify using external or internal standard method to calculate percentage of active ingredient (typically ≥98.0%). |
| Acid-Base Titration | Titrate carboxyl group with standardized sodium hydroxide solution using phenolphthalein as indicator; suitable for rough assay or supplementary verification. | |
| Enantiomeric Purity (ee Value) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Separate (S)- and (R)-enantiomers using a chiral stationary phase column; calculate enantiomeric excess (ee value) based on main peak area ratio, typically required to be ≥99%. |
| Moisture Content | Karl Fischer Titration | Determine trace moisture content; limit typically ≤0.5% (may be relaxed to 1.0% depending on application) to ensure stability and solubility. |
| Residual Solvents | Gas Chromatography (GC) | According to ICH Q3C guidelines, determine residual solvents such as methanol, ethanol, acetone, dichloromethane, etc., using headspace or direct injection; levels must meet regulatory limits. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect heavy metal content including lead, cadmium, mercury, arsenic, etc., in compliance with pharmacopoeial limits (e.g., lead ≤5 ppm). |
| Related Substances (Impurity Profile) | High-Performance Liquid Chromatography (HPLC) | Use gradient elution with UV detection (210–254 nm) to detect degradation products, unreacted starting materials, by-products, etc.; individual impurity ≤0.5%, total impurities ≤1.0%. |
| Chlorides, Sulfates | Colorimetric Method (Pharmacopoeial Method) | According to general chapters of the Chinese Pharmacopoeia, determine chloride and sulfate ion content by turbidimetry or precipitation method; comply with specified limits. |
| pH Value (Solution) | pH Meter Measurement | Prepare a 1% aqueous solution and measure pH (typically within range of 5.0–7.0), reflecting acid-base balance and purity. |
Technical Specifications of (S)-(+)-Nipecotic acid
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% |
| Optical Rotation | +5.0 to +6.0 deg (c=1, in 1M HCl) |
| Melting Point | 178 to 182 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-(+)-Nipecotic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-(+)-Nipecotic acid
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Industrial (S)-(+)-Nipecotic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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