L-Histidine hydrochloride monohydrate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 5934-29-2 |
| Product name | L-Histidine hydrochloride monohydrate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for L-Histidine hydrochloride monohydrate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk L-Histidine hydrochloride monohydrate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of L-Histidine hydrochloride monohydrate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesizing antiallergic agents, anti-inflammatory drugs, and adjuvants for gastrointestinal disease treatment | Used as an amino acid raw material in drug synthesis reactions; commonly employed in the production of peptide-based drug intermediates |
| Food Additives | Added as a nutritional fortificant to functional foods and infant formula | Subjected to pH adjustment and stabilization treatments to ensure bioavailability and stability during food processing |
| Biotechnology | Formulated into cell culture media to support cell growth and metabolism | Incorporated as an essential amino acid component into basal media to maintain cell viability and proliferative capacity |
| Chemical Reagents | Used as a reference standard or buffer component in biochemical assays | Accurately weighed and dissolved in laboratory settings for enzyme activity assays and pH buffer system construction |
| Research & Development | Applied in research on novel drug delivery systems, targeted formulations, and nanomaterials | Employed as a functional molecular modifier in covalent conjugation or self-assembly processes to enhance material biocompatibility |
Manufacturing Quality Control of L-Histidine hydrochloride monohydrate
| Test Item | Commonly Used Testing Methods | Method Overview |
|---|---|---|
| Identification Test | Infrared Spectrophotometry (IR) | Confirm the consistency of molecular structural characteristic peaks by comparing the IR spectrum with the standard spectrum. |
| Thin Layer Chromatography (TLC) | Develop the sample and reference substance on a silica gel plate, compare Rf values and color reactions to determine if they are the same substance. | |
| Specific Optical Rotation Determination | Measure the optical rotation at a specific wavelength (usually the sodium D-line, 589 nm) and temperature to verify optical purity and configuration. | |
| Assay | Non-aqueous Titration | Perform titration in a non-aqueous solvent (e.g., glacial acetic acid) using perchloric acid as titrant and crystal violet as indicator to determine the content of free base histidine. |
| High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with a UV detector (typically around 210 nm), and determine the main component content by external standard or area normalization method. | |
| pH Value | pH Meter Method | Prepare a solution of specified concentration (e.g., 1% or 0.1 mol/L), and measure the pH range using a calibrated pH meter. |
| Loss on Drying | Thermogravimetric Analysis / Drying and Weight Loss Method | Dry the sample at a specified temperature (e.g., 105°C) to constant weight, calculate the percentage weight loss to assess moisture and volatile content. |
| Sulfated Ash (Residue on Ignition) | High-Temperature Ignition Method | After charring, ignite the sample in a high-temperature furnace at 700–800°C, weigh the residual inorganic matter to assess total inorganic impurities. |
| Heavy Metals | Thioacetamide Colorimetry (or Atomic Absorption Spectroscopy) | In acidic conditions, react with thioacetamide to form colored precipitates for colorimetric determination; or use atomic absorption spectroscopy to quantify heavy metals such as lead and cadmium. |
| Chlorides | Silver Nitrate Turbidimetry | In nitric acid medium, react with silver nitrate to form silver chloride turbidity, compare with standard sodium chloride solution for chloride ion limit control. |
| Sulfates | Barium Chloride Turbidimetry | In hydrochloric acid medium, react with barium chloride to form barium sulfate precipitate, determine sulfate impurities by turbidity comparison. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separate and detect potential organic impurities (e.g., D-isomers, degradation products) using gradient or isocratic elution, usually quantified by area normalization or with correction factors. |
| Amino Acid Composition / Purity | Amino Acid Analyzer (Ion Exchange Chromatography) | After acid hydrolysis (if required), separate amino acid components by cation exchange chromatography, and detect using ninhydrin colorimetry. |
| Water Content | Karl Fischer Titration | Quantitatively react Karl Fischer reagent with water in the sample, determine the endpoint by potentiometric or coulometric method to accurately measure total water content including crystalline and adsorbed water. |
| Microbial Limits | Microbial Culture Method | Perform testing according to pharmacopoeia requirements for total aerobic microbial count, total mold and yeast count, and specified microorganisms (e.g., Escherichia coli, Salmonella). |
Technical Specifications of L-Histidine hydrochloride monohydrate
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 272-276 °C (decomposes) |
| Optical Rotation | +8.5 to +9.5 (c=1, 1M HCl) |
| Total Impurities | <=1.5% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of L-Histidine hydrochloride monohydrate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of L-Histidine hydrochloride monohydrate
Safety Information of L-Histidine hydrochloride monohydrate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of L-Histidine hydrochloride monohydrate
Industrial L-Histidine hydrochloride monohydrate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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