H-Lys(Z)-OtBu.HCl Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 5978-22-3 |
| Product name | H-Lys(Z)-OtBu.HCl |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for H-Lys(Z)-OtBu.HCl
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk H-Lys(Z)-OtBu.HCl Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of H-Lys(Z)-OtBu.HCl
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Protecting reagent for lysine residues in peptide synthesis | Used as a side-chain protecting group in Fmoc-based solid-phase peptide synthesis (SPPS) to introduce protected lysine units; the hydrochloride salt form facilitates dissolution and coupling reactions |
| Biochemical Research | Modification intermediate for protein/peptide structure and function studies | Provides orthogonal protection in liquid-phase peptide synthesis and fragment condensation; benzyloxycarbonyl (Cbz) and tert-butyl (Boc) groups enable selective deprotection of the α-amino and side-chain amino groups |
| Fine Chemicals | Key synthetic intermediate for chiral drugs and peptide-based APIs | Cbz group removed via catalytic hydrogenolysis or HBr/acetic acid, followed by tert-butyl ester removal with TFA to liberate the free lysine side chain; the hydrochloride salt form enhances crystallinity and storage stability |
Manufacturing Quality Control of H-Lys(Z)-OtBu.HCl
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical state, and presence of foreign matter under natural light or standard illumination. It should appear as a white to off-white crystalline powder. |
| Identification | Infrared Spectroscopy (IR) Nuclear Magnetic Resonance Hydrogen Spectroscopy (¹H NMR) |
IR: Record the infrared absorption spectrum of the sample and compare characteristic absorption peaks (e.g., amide C=O, benzene ring, tert-butyl groups) with reference spectra. ¹H NMR: Measure the proton NMR spectrum in deuterated solvent; confirm characteristic chemical shifts (e.g., benzyl, tert-butyl, lysine backbone protons), ensuring consistency with theoretical structure. |
| Purity / Related Substances | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with phosphate buffer-acetonitrile or methanol-water mobile phase for gradient elution, detected by UV detector (typically 210–220 nm). Calculate main component content and impurity peak areas using area normalization or reference standard method to assess purity and degradation products. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) Acid-Base Titration |
HPLC: Same chromatographic conditions as above; determine active ingredient content using external standard or internal standard method, expressed on a dried basis. Acid-Base Titration: Exploit the hydrochloride salt property by titrating free acid form with standardized sodium hydroxide solution to indirectly calculate content (less commonly used for high-purity APIs, typically applied for initial screening of crude materials). |
| Water Content | Karl Fischer Titration | Determine moisture content using either volumetric or coulometric Karl Fischer titration. Suitable for samples containing water of crystallization or hygroscopic substances; controls moisture level to ensure product stability. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace injection or direct injection with polar or non-polar capillary columns and FID detection. Analyze residual organic solvents (e.g., dichloromethane, methanol, ethyl acetate, tert-butanol) according to ICH Q3C guidelines from synthesis or purification processes. |
| Residue on Ignition / Ash Content | Residue on Ignition Test Method | Ignite the sample at high temperature (typically 700–800°C), then weigh the residual inorganic matter to assess levels of inorganic impurities. |
| Specific Rotation | Polarimetry | Prepare a solution of specified concentration (e.g., 1% w/v in methanol or water), measure optical rotation at a defined wavelength (usually 589 nm, sodium D-line) and temperature, then calculate specific rotation to verify stereochemical purity and structural consistency. |
| pH (if formulated as solution) | pH Meter Measurement | Dissolve the sample into a specified concentration aqueous solution (e.g., 1% w/v), then measure pH using a calibrated pH meter to evaluate acidity/alkalinity—typically acidic due to the hydrochloride salt form. |
Technical Specifications of H-Lys(Z)-OtBu.HCl
| Test Item | Specification |
|---|---|
| Appearance | White powder |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148–152°C |
| Optical Rotation | +13 ±2° (c=1, in 6N HCl) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of H-Lys(Z)-OtBu.HCl
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of H-Lys(Z)-OtBu.HCl
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Industrial H-Lys(Z)-OtBu.HCl Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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