1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 6001-64-5 |
| Product name | 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
| Industry | Application | Process |
|---|---|---|
| Pesticide Intermediates | Key intermediate for synthesizing pyrethroid insecticides (e.g., cypermethrin, beta-cyfluthrin) | Undergoes nucleophilic substitution with cyanide compounds (e.g., sodium cyanide), followed by hydrolysis and cyclization to form chrysanthemic acid derivatives |
| Pharmaceutical Intermediates | Used to construct side-chain structures of certain antifungal and cardiovascular drugs | Serves as a chiral starting material; active molecular fragments are built via selective reduction and functional group transformations |
| Organic Synthesis | Employed as a chlorohydrin reagent in nucleophilic substitution, elimination, and epoxidation reactions | Undergoes dehydrochlorination to methylacrolein under basic conditions, or participates in coupling reactions with organometallic reagents |
Manufacturing Quality Control of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
| Test Item | Common Testing Method | Method Summary |
|---|---|---|
| Appearance and Properties | Visual Inspection, Microscopic Observation | Observe that the sample is a white or off-white crystalline powder with no visible foreign matter. It should meet the descriptions in pharmacopoeia or enterprise standards regarding shape, color, and crystallinity. The hemihydrate form should exhibit a specific crystal type; microscopic observation may be used to examine crystal morphology if necessary. |
| Identification | Infrared Spectroscopy (IR) | Use a Fourier Transform Infrared Spectrometer (FT-IR) to compare the characteristic absorption peaks of the sample and standard reference material within the range of 4000–400 cm⁻¹, such as C–Cl stretching vibration (~750 cm⁻¹), O–H stretching (~3300 cm⁻¹), and C–OH bending vibrations, confirming chemical structural consistency. |
| Identification | Nuclear Magnetic Resonance Hydrogen Spectrum (¹H NMR) | Determine the ¹H NMR spectrum of the sample in deuterated solvents (e.g., DMSO-d₆ or CDCl₃). Characteristic peaks include a singlet for methyl groups on tertiary carbon (δ ~1.7 ppm), hydroxyl proton peak (δ ~3.5–4.5 ppm, affected by hydrogen bonding), and water signal (~4–5 ppm). Compare with standard spectra to confirm the structure. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a C18 reverse-phase chromatographic column with a mobile phase consisting of methanol-water or acetonitrile-water (with small amounts of acid or buffer salt). A UV detector (wavelength 210–230 nm) is used for detection. Quantify the main component content using external standard or internal standard methods, ensuring it meets specified limits (e.g., ≥98.0%). |
| Content Determination | Gas Chromatography (GC) | Suitable for analyzing volatile components. The sample can be derivatized or directly injected (thermal stability must be considered). Use an FID detector to quantify retention time and peak area. Applicable for detecting residual solvents or degradation products. |
| Water Content | Karl Fischer Titration | Determine the total content of crystallization water and free water using volumetric or coulometric methods. For hemihydrates, the theoretical water content is approximately 6.5%, and the measured value should fall within ±0.5% of this value to ensure stable hydration state. |
| Related Substances | High-Performance Liquid Chromatography (HPLC) | Use gradient or isocratic elution to detect possible degradation products such as trichlorobutanol dehydration products (e.g., trichloroisobutylene), oxidation products, or unreacted raw materials. Specify single impurity and total impurity limits (e.g., ≤0.5%, ≤1.0%) and calculate using area normalization or external standard methods. |
| Chlorine Content Determination | Combustion-Ion Chromatography / Oxygen Bomb Combustion + Ion Selective Electrode | The sample is combusted in an oxygen bomb and converted into chloride ions, which are quantitatively determined using ion chromatography or chloride-selective electrode. Verify the total chlorine content corresponding to three chlorine atoms in the molecule (theoretical value ~68.5%), with a deviation within ±1.5%. |
| Solubility | Solubility Test Method | Determine solubility in common solvents such as water, ethanol, and ether at 25°C. It should comply with pharmacopoeial specifications (e.g., soluble in ethanol, slightly soluble in water), serving as an auxiliary criterion for purity assessment. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Loss on Drying Method | Dry to constant weight at 105°C to measure the loss rate of non-volatile substances. This should be consistent with Karl Fischer results, confirming that only crystallization water is present without other volatile impurities. |
| Heavy Metals | Atomic Absorption Spectrometry (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Determine the content of heavy metals such as lead, cadmium, mercury, and arsenic after sample digestion. These should meet pharmacopoeial limits (e.g., ≤10 ppm) to ensure safety. |
| Microbial Limits | Pharmacopoeial Microbial Limit Test Method | Perform microbial limit testing according to the Chinese Pharmacopoeia or USP requirements, including aerobic bacterial count, mold and yeast count, Escherichia coli, etc., for microbiological control prior to pharmaceutical use. |
Technical Specifications of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
| Test Item | Specification |
|---|---|
| Appearance | White to Light yellow powder to crystal |
| Purity | ≥98.0% |
| Water | ≤5.0% |
| Chlorides | ≤100 ppm |
| Acidity | ≤1.0 ml of 0.01M NaOH |
| Sulphated Ash | ≤0.1% |
| Chloroform | ≤60 ppm |
| Acetone | ≤0.1% |
| Total Bacterial Count | ≤1000 cfu/g |
| Yeast and Mold | ≤10 cfu/g |
| Escherichia coli | ND |
| Salmonella | ND |
| Pseudomonas Aeruginosa | ND |
| Staphylococcus Aureus | ND |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
Safety Information of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
Industrial 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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