DOTA Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 60239-18-1 |
| Product name | DOTA |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for DOTA
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk DOTA Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of DOTA
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Used in the preparation of radiopharmaceuticals as a chelating ligand for radioactive isotopes (e.g., gadolinium, copper, yttrium) for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) | Chelation of DOTA with specific radioactive metal ions via chemical synthesis for labeling antibodies or peptide-based drugs |
| Nuclear Medicine | Used as a ligand in MRI contrast agents to enhance magnetic resonance imaging contrast | Formation of stable chelates with paramagnetic metal ions (e.g., gadolinium) to improve image clarity |
| Biotechnology | Used for labeling biomolecules (e.g., proteins, antibodies, peptides) in research and diagnostics | Covalent conjugation of DOTA to biomolecules followed by metal ion binding to achieve functionalization |
| Materials Science | Used in the preparation of functional materials, such as fluorescent probes or sensors | Incorporation of metal ions into materials via DOTA’s chelating capability to impart specific functionality |
Manufacturing Quality Control of DOTA
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (DOTA content) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 210 nm, calibrated against certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., tri-, di-, mono-acid analogs, linear isomers) using gradient HPLC-UV. |
| Residual Solvents | GC-FID | Identification and quantification of residual solvents (e.g., methanol, acetonitrile, DMF) by gas chromatography with flame ionization detection. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As, Ni, Cu) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Chloride Content | Ion Chromatography | Quantification of chloride ions using suppressed ion chromatography with conductivity detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric determination of water based on the stoichiometric reaction of iodine with water in pyridine/methanol medium. |
| pH (1% w/v aqueous solution) | pH Meter | Measurement of hydrogen ion activity in a standardized aqueous solution using calibrated pH electrode. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of solid sample or its aqueous solution under controlled lighting conditions. |
| Melting Point | DSC | Determination of thermal transition onset temperature using differential scanning calorimetry under nitrogen purge. |
| Loss on Drying | Gravimetric Analysis | Mass loss measured after drying sample at 105 C for 2 hours under vacuum or forced-air oven. |
| Residue on Ignition | Gravimetric Analysis | Weight of non-volatile inorganic residue after charring and ashing at 600 C in a muffle furnace. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic mesophilic microorganisms and absence testing for specified pathogens per pharmacopeial methods. |
Technical Specifications of DOTA
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 238-242°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of DOTA
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of DOTA
Packaging of DOTA
Industrial DOTA Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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