(S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 60456-22-6 |
| Product name | (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral synthetic intermediate for preparing β-blockers (e.g., (S)-propranolol) and other chiral drug molecules | Used as a chiral building block in asymmetric synthesis; the chloromethyl functional group is introduced via nucleophilic substitution or coupling reactions |
| Agrochemicals | Intermediate for synthesizing chiral pesticides | Applied to construct the chiral-active ingredient backbone |
| Organic Synthesis | Chiral auxiliary or protecting group carrier | The acetal structure protects carbonyl groups and is subsequently cleaved to regenerate the functional group |
Manufacturing Quality Control of (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Gas Chromatography (GC) with FID detector | Quantitative determination based on peak area comparison against a certified reference standard using a non-polar capillary column. |
| Enantiomeric Excess (ee) | Chiral Gas Chromatography (chiral-GC) | Separation of (R)- and (S)-enantiomers on a chiral stationary phase; ee calculated from peak area ratio. |
| Residual Solvents | Headspace Gas Chromatography (HS-GC) | Volatile organic solvents quantified by equilibrium partitioning into headspace followed by GC-FID analysis. |
| Water Content | Karl Fischer Titration (coulometric mode) | Electrochemical titration where iodine generated in situ reacts stoichiometrically with water in the sample. |
| Acid Value | Acid-Base Titration (NaOH standard solution) | Neutralization of acidic impurities with standardized sodium hydroxide solution using phenolphthalein indicator. |
| Chloride Content | Ion Chromatography (IC) with conductivity detection | Separation and quantification of chloride anions via ion-exchange column and suppressed conductivity detection. |
| Heavy Metals (Pb, Cd, Hg, As) | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Multi-element trace metal quantification after acid digestion and plasma ionization with high mass resolution. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against standard white background under controlled lighting. |
| Specific Optical Rotation | [alpha]D Measurement using Polarimeter | Measurement of rotation angle of plane-polarized light at 589 nm to confirm chiral integrity and concentration. |
| Residue on Ignition | Gravimetric Analysis (Weight Loss on Ignition) | Mass difference before and after high-temperature ashing to determine inorganic residue content. |
| Related Substances | High Performance Liquid Chromatography (HPLC) with UV detection | Separation and quantification of structurally related impurities using reversed-phase C18 column and UV absorbance at 210 nm. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Determination of hydrogen ion activity in a 1% w/v aqueous solution using calibrated glass electrode and pH meter. |
Technical Specifications of (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
| Test Item | Specification |
|---|---|
| Appearance | Colorless liquid |
| Purity | >=98.0% (GC-MS) |
| Optical Rotation | -46° to -40° (c=1, in CHCl3) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Refractive Index (n20/D) | 1.440–1.450 |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
Safety Information of (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
| Pictograms |    |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane
Industrial (S)-(-)-4-Chloromethyl-2,2-dimethyl-1,3-dioxolane Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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