(4R)-4-FLUORO-L-PROLINE HCL Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 60604-36-6 |
| Product name | (4R)-4-FLUORO-L-PROLINE HCL |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (4R)-4-FLUORO-L-PROLINE HCL
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (4R)-4-FLUORO-L-PROLINE HCL Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (4R)-4-FLUORO-L-PROLINE HCL
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral auxiliaries and intermediates for synthesizing fluorinated proline-containing active pharmaceutical ingredients (e.g., antiviral and anticancer candidates) | Used as a configurationally stable fluorinated amino acid monomer in solid-phase peptide synthesis; or employed in coupling reactions following protection/deprotection |
| Pharmaceutical R&D | Construction of fluorinated heterocyclic peptide libraries for high-throughput screening | Applied as a chiral building block in cross-coupling or condensation reactions, including Ugi and Buchwald–Hartwig reactions |
| Biochemical Research | Investigation of the impact of fluorine substitution at proline residues on protein secondary structure stability (e.g., polyproline helices, β-turns) and enzyme recognition specificity | Dissolved in buffered systems for in vitro peptide chain elongation or site-specific mutagenesis simulation experiments |
Manufacturing Quality Control of (4R)-4-FLUORO-L-PROLINE HCL
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by reverse-phase HPLC with UV detection at 210 nm, using a certified reference standard for calibration. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase; trans-4-fluoro-L-proline peak area ratio vs. total proline-related peaks. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration with iodine-based reagent to determine water via stoichiometric reaction. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection, using internal standard for quantitation of common solvents (e.g., methanol, acetone). |
| Heavy Metals | ICP-OES | Multi-element detection after acid digestion; measures total metal content (Pb, Cd, Hg, As, Ni) by atomic emission. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode; endpoint detected by potential change. |
| pH (1% w/v aqueous solution) | pH Meter Measurement | Direct measurement of hydrogen ion activity in a standardized aqueous solution at 25 C. |
| Related Substances | HPLC-UV | Detection and quantification of impurities (e.g., cis-isomer, N-defluorinated analogs) using gradient HPLC-UV. |
| Loss on Drying | Gravimetric Analysis | Weight loss after drying under controlled temperature and vacuum; reflects volatile matter and residual moisture. |
| Optical Rotation | [alpha]D Measurement | Specific rotation measured using sodium D-line light source in a calibrated polarimeter; confirms chiral integrity. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity to determine volume-based particle size distribution in dry dispersion mode. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and absence of specified pathogens per pharmacopeial guidelines. |
Technical Specifications of (4R)-4-FLUORO-L-PROLINE HCL
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 215-220°C (decomposes) |
| Optical Rotation | +18.0° to +22.0° (c=1, H2O) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (4R)-4-FLUORO-L-PROLINE HCL
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (4R)-4-FLUORO-L-PROLINE HCL
Packaging of (4R)-4-FLUORO-L-PROLINE HCL
Industrial (4R)-4-FLUORO-L-PROLINE HCL Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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