6-Mercaptopurine monohydrate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 6112-76-1 |
| Product name | 6-Mercaptopurine monohydrate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 6-Mercaptopurine monohydrate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 6-Mercaptopurine monohydrate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 6-Mercaptopurine monohydrate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Active pharmaceutical ingredient (API) for anticancer drugs | Used in the synthesis of immunosuppressants and antileukemic agents such as azathioprine; acts by inhibiting the de novo purine nucleotide biosynthesis pathway |
| Pharmaceuticals | Immunosuppressant | Applied in the treatment of acute lymphoblastic leukemia, chronic myeloid leukemia, and autoimmune disorders including Crohn’s disease and ulcerative colitis |
| Biochemical Research | Enzyme inhibitor and reagent for metabolic studies | Functions as an inhibitor of xanthine oxidase and other enzymes involved in purine metabolism; used in in vitro biochemical assays to investigate purine metabolic pathways |
Manufacturing Quality Control of 6-Mercaptopurine monohydrate
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Identification | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Utilizes characteristic absorption peaks of 6-mercaptopurine at specific wavelengths (e.g., around 254 nm and 318 nm) for qualitative identification. |
| Fourier Transform Infrared Spectroscopy (FTIR) | Confirms functional groups in the molecular structure by comparing the sample's infrared absorption spectrum with a reference spectrum. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase column (e.g., C18) and a UV detector (around 254 nm) with external or internal standard method to quantify the main component. |
| Ultraviolet Spectrophotometry (UV) | Measures absorbance at the maximum absorption wavelength and calculates concentration using a calibration curve; suitable for rapid determination of high-purity samples. | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Employs gradient or isocratic elution to separate impurities, detect degradation products or synthesis intermediates, and evaluate purity and impurity limits. |
| Water Content (Monohydrate) | Karl Fischer Titration | Accurately measures total water content (bound and free water) to verify compliance with the theoretical water content of monohydrate (~7.8%). |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Method | Heats the sample at a specified temperature to determine weight loss, assessing residual solvents and crystalline water content. |
| Sulfated Ash (Residue on Ignition) | Ignition after Sulfation | The sample is treated with sulfuric acid and then ignited at high temperature (about 600–800°C); the residue is weighed to estimate inorganic impurity content. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, determines levels of heavy metal elements such as lead, cadmium, mercury, and arsenic to ensure compliance with pharmacopoeial limits. |
| Crystal Form Analysis | X-Ray Powder Diffraction (XRD) | Analyzes characteristic peaks of crystal structure to confirm the presence of polymorphs and ensure batch-to-batch consistency. |
| Particle Size Distribution | Laser Diffraction Analysis (LDI) | Measures particle size distribution, which affects solubility and formulation performance, particularly important for raw material control in solid dosage forms. |
| Solution Clarity and Color | Visual Comparison or Spectrophotometry | The sample solution is compared visually or instrumentally with standard color solutions to assess clarity and color against specifications. |
Technical Specifications of 6-Mercaptopurine monohydrate
| Test Item | Specification |
|---|---|
| Appearance | Light yellow to yellow powder or crystals |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | >300°C (decomposes) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 6-Mercaptopurine monohydrate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 6-Mercaptopurine monohydrate
Packaging of 6-Mercaptopurine monohydrate
Industrial 6-Mercaptopurine monohydrate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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