cis-4-Hydroxy-L-proline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 618-27-9 |
| Product name | cis-4-Hydroxy-L-proline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for cis-4-Hydroxy-L-proline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk cis-4-Hydroxy-L-proline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of cis-4-Hydroxy-L-proline
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Key intermediate in peptide drug synthesis | Used as a non-natural amino acid monomer in solid-phase or solution-phase peptide synthesis to construct peptide drug molecules with specific biological activity (e.g., anticancer, antiviral agents). |
| Pharmaceutical Chemicals | Chiral drug and building block synthesis feedstock | Serves as a chiral starting material for chemical transformations (e.g., oxidation, reduction, substitution) to synthesize other chiral drug intermediates or active pharmaceutical ingredients (APIs). |
| Pharmaceutical Chemicals | Collagen inhibitor synthesis | Acts as a core structural unit in synthesizing specific enzyme inhibitors (e.g., prolyl hydroxylase inhibitors or collagen synthesis inhibitors) for antifibrotic drug development. |
| Biomedical Research | Reagent for collagen structural studies | Employed as a proline analog in cell biology experiments; incorporated into peptide chains to disrupt normal collagen triple-helix formation, enabling investigation of extracellular matrix metabolism mechanisms. |
| Cosmetics | Functional ingredient precursor | Serves as a precursor for chemical modification to synthesize bioactive peptides with antioxidant or skin-repair properties, used in high-end skincare formulation development. |
| Organic Synthesis | Chiral catalyst/ligand development | Leverages its rigid pyrrolidine ring structure and chiral center to prepare chiral catalysts or ligands via derivatization reactions for asymmetric catalytic systems. |
Manufacturing Quality Control of cis-4-Hydroxy-L-proline
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC with UV detection | Quantitative determination using reversed-phase HPLC and UV absorbance at 200-220 nm relative to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase; quantification of L-isomer content versus D-isomer impurity. |
| Loss on Drying | Gravimetric thermogravimetry | Mass loss measured after drying at 105 C for 2 hours under atmospheric pressure. |
| Residue on Ignition | Sulfated ash gravimetry | Residue mass after controlled ignition at 600-700 C following sulfuric acid treatment. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after acid digestion. |
| Chloride Impurity | Potentiometric titration with AgNO3 | Titration using silver nitrate and silver indicator electrode; endpoint detected by potential change. |
| Sulfate Impurity | Turbidimetric assay | Formation of barium sulfate precipitate measured by light scattering at 420 nm. |
| pH of Aqueous Solution | Potentiometric pH measurement | Measurement of hydrogen ion activity in a 1% w/v aqueous solution using calibrated glass electrode. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light at 20 C using sodium D-line (589 nm). |
| Related Substances | HPLC with gradient elution | Separation and quantification of structurally similar impurities using UV detection and area normalization. |
| Water Content | Karl Fischer titration | Volumetric or coulometric determination of water based on iodine-sulfur dioxide reaction stoichiometry. |
| Microbial Limits | Membrane filtration and colony counting | Enumeration of aerobic mesophilic microorganisms after filtration, membrane transfer, and incubation on TSA. |
Technical Specifications of cis-4-Hydroxy-L-proline
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 215-220 °C (dec.) |
| Optical Rotation | -60.0 to -56.0 ° (c=1, H2O) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of cis-4-Hydroxy-L-proline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of cis-4-Hydroxy-L-proline
Packaging of cis-4-Hydroxy-L-proline
Industrial cis-4-Hydroxy-L-proline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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