trans-4-Aminoadamantan-1-ol hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 62075-23-4 |
| Product name | trans-4-Aminoadamantan-1-ol hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for trans-4-Aminoadamantan-1-ol hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk trans-4-Aminoadamantan-1-ol hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of trans-4-Aminoadamantan-1-ol hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of antiviral agents (e.g., adamantane derivatives) | Employed in multistep organic synthesis, participating in acylation, alkylation, or coupling reactions to construct active molecular scaffolds |
| Pharmaceuticals | Precursor compound for developing therapeutics targeting neurodegenerative disorders (e.g., Parkinson’s disease) | Undergoes functional group transformations under controlled conditions to introduce specific pharmacophores and optimize pharmacokinetic properties |
| Chemical Research | Nitrogen- and hydroxyl-functionalized rigid alicyclic building block | Used to construct complex molecules with defined stereochemistry for structure–activity relationship studies in medicinal chemistry and materials science |
Manufacturing Quality Control of trans-4-Aminoadamantan-1-ol hydrochloride
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection + Physical Property Measurement | Observe sample color and state (white or off-white crystalline powder), determine melting point range (literature value approximately 200–215 °C), and assess compliance with pharmacopoeial or company specifications. |
| Identification Test | Infrared Spectroscopy (IR) | Compare characteristic absorption peaks (e.g., N–H stretching vibration ~3300 cm⁻¹, O–H ~3200 cm⁻¹, C–N ~1200 cm⁻¹) with reference spectra to confirm molecular structure. |
| High-Performance Liquid Chromatography (HPLC) | Compare retention times using reference standards under identical chromatographic conditions (e.g., C18 column, water-methanol gradient elution) to confirm the identity of the main component peak. | |
| Nuclear Magnetic Resonance Spectroscopy (¹H-NMR / ¹³C-NMR) | Confirm molecular structure and configuration (trans) based on characteristic chemical shifts in proton and carbon NMR spectra (e.g., adamantane protons δ 1.5–2.5 ppm, amino protons δ ~2.5–3.5 ppm). | |
| Content Determination | High-Performance Liquid Chromatography with UV Detection (HPLC-UV) | Quantify the active ingredient using external standard or internal standard method, with UV detection at λ = 210–220 nm. Chromatographic conditions are validated for linearity, precision, accuracy, and other methodological parameters. |
| Non-aqueous Titration | Titrate free amino groups in glacial acetic acid medium using standardized perchloric acid solution, with crystal violet as indicator; suitable for total alkalinity determination in hydrochloride form. | |
| Impurity Profiling Analysis | High-Performance Liquid Chromatography with UV/MS Detection (HPLC-UV/MS) | Use gradient elution to separate impurities; UV detection limit typically ≤0.1%. Combine with mass spectrometry (LC-MS) to identify unknown impurities (e.g., deamination products, oxidation products, isomers). |
| Water Content Determination | Karl Fischer Titration | Determine residual moisture content using either volumetric or coulometric Karl Fischer method, controlled at ≤0.5% (based on dosage form requirements), ensuring product stability. |
| Residual Solvents | Gas Chromatography (GC) | Detect potentially residual organic solvents such as ethanol, acetone, dichloromethane via headspace or direct injection, complying with ICH Q3C guidelines. |
| Chloride Ion Content | Ion Chromatography (IC) or Precipitation Titration | Determine chloride ion concentration using ion chromatography or silver nitrate titration; verify Cl⁻ content matches theoretical value (theoretical Cl⁻ content ~22.5%) in hydrochloride salt form. |
| Heavy Metals and Metal Ions | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Test for toxic heavy metals such as lead, cadmium, mercury, and arsenic, controlled at ≤10 ppm, meeting pharmaceutical standards (e.g., USP/EP). |
| Solution Clarity and Color | Visible Spectrophotometry / Visual Color Comparison | Prepare a solution at specified concentration; visually inspect or use a spectrophotometer to measure transmittance in the 400–700 nm range, ensuring no visible turbidity or abnormal discoloration. |
| Polymorph Analysis (if applicable) | X-ray Powder Diffraction (XRPD) | Used to confirm consistent crystalline form (polymorph), preventing variability in solubility and stability due to different crystal forms. |
Technical Specifications of trans-4-Aminoadamantan-1-ol hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 215–220 °C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Optical Rotation | -1.0 to +1.0 ° (c=1, H2O) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of trans-4-Aminoadamantan-1-ol hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Safety Information of trans-4-Aminoadamantan-1-ol hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of trans-4-Aminoadamantan-1-ol hydrochloride
Industrial trans-4-Aminoadamantan-1-ol hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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