tert-Butyl 2-(dimethoxyphosphoryl)acetate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 62327-21-3 |
| Product name | tert-Butyl 2-(dimethoxyphosphoryl)acetate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for tert-Butyl 2-(dimethoxyphosphoryl)acetate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk tert-Butyl 2-(dimethoxyphosphoryl)acetate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of tert-Butyl 2-(dimethoxyphosphoryl)acetate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Key intermediate for antiviral drugs (e.g., tenofovir, tenofovir alafenamide fumarate) | Constructs the phosphonyl group via the Arbuzov or Michaelis–Arbuzov reaction; serves as a phosphonylating reagent to introduce the phosphonic acid moiety |
| Pharmaceutical Industry | Synthesis of nucleoside (nucleotide) analogues | Undergoes nucleophilic substitution or condensation with purine or pyrimidine derivatives to form carbon–phosphorus bonds |
| Agrochemical Industry | Synthesis of organophosphorus herbicides and insecticides | Serves as a phosphonyl-containing acetate structural unit, participating in condensation or addition reactions to synthesize target agrochemical molecules |
| Fine Chemicals | R&D of active pharmaceutical ingredients (APIs) and advanced intermediates | Leverages its dual functional groups—phosphonyl and ester—for selective hydrolysis, reduction, or coupling reactions |
| Biochemistry | Synthesis of nucleotide analogues | Mimics natural nucleotide structures to synthesize biologically active phosphonate ester derivatives |
Manufacturing Quality Control of tert-Butyl 2-(dimethoxyphosphoryl)acetate
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, state, and clarity of the sample under natural or standard light to determine the presence of impurities or precipitates. |
| Content Determination | Gas Chromatography (GC) or High-Performance Liquid Chromatography (HPLC) | Use an appropriate chromatographic column and detector (e.g., FID or UV), and quantify the main component content by comparing retention times and peak areas with standard samples. |
| Purity Analysis | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase column (e.g., C18), gradient or isocratic elution, detect impurity peaks, and calculate total impurity content and main peak purity. |
| Residual Solvents | Gas Chromatography (GC) | According to ICH guidelines, detect residual organic solvents (e.g., methanol, ethyl acetate, etc.) from the production process using headspace sampling. |
| Moisture Content | Karl Fischer Titration | Determine the water content in the sample precisely based on the reaction between iodine and sulfur dioxide in an anhydrous environment. |
| Acid Value / Free Acids | Acid-Base Titration | Titrate free acidic impurities in the sample with a standard sodium hydroxide solution and calculate the acid value (mg KOH/g). |
| Phosphorus Content Determination | Spectrophotometry or ICP-OES | After digestion, use molybdenum blue colorimetry or Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) to determine phosphorus content. |
| Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Analyze the compound structure via ¹H-NMR and ³¹P-NMR to confirm the chemical structure and substitution positions of the target product. |
| Infrared Characteristic Absorption | Fourier Transform Infrared Spectroscopy (FT-IR) | Compare with standard spectra to confirm the presence of characteristic functional groups (e.g., P=O, C=O, C–O, etc.). |
| Thermal Stability | Differential Scanning Calorimetry (DSC) | Determine the endothermic or exothermic behavior of the sample during heating to assess its melting point, decomposition temperature, and thermal stability. |
Technical Specifications of tert-Butyl 2-(dimethoxyphosphoryl)acetate
| Test Item | Specification |
|---|---|
| Appearance | Colorless to almost colorless, clear liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.425–1.435 |
| Relative Density (20°C/25°C) | 1.08–1.12 g/cm³ |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of tert-Butyl 2-(dimethoxyphosphoryl)acetate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of tert-Butyl 2-(dimethoxyphosphoryl)acetate
Safety Information of tert-Butyl 2-(dimethoxyphosphoryl)acetate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of tert-Butyl 2-(dimethoxyphosphoryl)acetate
Industrial tert-Butyl 2-(dimethoxyphosphoryl)acetate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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