Cbz-L-tert-Leucine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 62965-10-0 |
| Product name | Cbz-L-tert-Leucine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Cbz-L-tert-Leucine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Cbz-L-tert-Leucine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Cbz-L-tert-Leucine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key chiral building block for synthesizing antiviral agents (e.g., HIV protease inhibitors) | Used as an amino-protecting group (Cbz protection) in solid-phase peptide synthesis; removed subsequently via hydrogenolysis |
| Pharmaceutical Intermediates | Chiral side-chain building block for novel anticancer agents and targeted small-molecule inhibitors | Introduced onto heterocyclic scaffolds via coupling reactions (e.g., Suzuki, Heck); followed by deprotection and salt formation |
| Organic Synthesis | Chiral auxiliary or precursor to chiral ligands for asymmetric catalysis | Converted to acyl chloride, then condensed with chiral amines to prepare chiral bidentate ligands for asymmetric alkylation |
Manufacturing Quality Control of Cbz-L-tert-Leucine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 210–220 nm, comparing peak area against a certified reference standard. |
| Enantiomeric Purity | Chiral HPLC | Separation of L- and D-enantiomers on a chiral stationary phase, with UV detection and calculation of enantiomeric excess (ee). |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., ethyl acetate, methanol, toluene) per ICH Q3C guidelines. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, achieving sub-pptr detection limits. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content based on stoichiometric reaction. |
| Residue on Ignition | Gravimetric Analysis | Incineration at 700–800 °C followed by weighing of inorganic residue to assess inorganic impurities. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light at 20 °C using sodium D-line (589 nm) to confirm chiral integrity and concentration. |
| Related Substances | HPLC-UV (with gradient elution) | Detection and quantification of structurally related impurities (e.g., de-Cbz product, diastereomers, hydrolysis products) using validated stability-indicating method. |
| pH (in aqueous suspension) | pH Meter | Measurement of pH in a defined saturated aqueous suspension (e.g., 1% w/v) to assess acidic/basic degradation propensity. |
| Particle Size Distribution | Laser Diffraction | Dry or wet dispersion followed by light scattering analysis to determine D10, D50, D90 values relevant for handling and formulation. |
| Melting Point | Differential Scanning Calorimetry (DSC) | Thermal analysis to determine onset and range of melting transition, confirming identity and crystallinity. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and absence testing for specified pathogens per USP <61> and <62>. |
Technical Specifications of Cbz-L-tert-Leucine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=99.0% (by LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 82–86°C |
| Optical Rotation | -6.5 to -5.5° (c=1, in CHCl3) |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Cbz-L-tert-Leucine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Cbz-L-tert-Leucine
Packaging of Cbz-L-tert-Leucine
Industrial Cbz-L-tert-Leucine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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