4-Pyridyl acetone Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 6304-16-1 |
| Product name | 4-Pyridyl acetone |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Pyridyl acetone
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Pyridyl acetone Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Pyridyl acetone
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of the antitumor drug palbociclib | Used to prepare palbociclib via multi-step reactions including reductive amination and cyclization with 4-aminopyridine |
| Pharmaceuticals | Used in the synthesis of other kinase inhibitor candidates | Applied as a pyridyl-containing β-ketoamine structural unit to construct the core scaffold of CDK4/6 inhibitors |
| Organic Synthesis | Multifunctional synthon for constructing complex molecules containing pyridine heterocycles | Functionalized via enolization, alkylation, halogenation, Suzuki coupling, and related reactions |
Manufacturing Quality Control of 4-Pyridyl acetone
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Gas Chromatography (GC) with FID detection | Quantitative determination based on peak area comparison against a certified reference standard under optimized chromatographic conditions. |
| Related Substances | High Performance Liquid Chromatography (HPLC) with UV detection | Separation and quantification of impurities using a reversed-phase column and UV absorbance at 254 nm. |
| Residual Solvents | Headspace Gas Chromatography (HS-GC) with FID | Volatile solvent residues are extracted into headspace and quantified by GC-FID using calibrated standards. |
| Water Content | Karl Fischer Titration (Coulometric mode) | Electrochemical titration where iodine generated in situ reacts stoichiometrically with water in the sample. |
| Acid Value | Acid-Base Titration with NaOH standard solution | Neutralization of acidic impurities using standardized sodium hydroxide solution and potentiometric endpoint detection. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against specified criteria in a clear glass container under controlled lighting. |
| Melting Point | Capillary Melting Point Determination | Thermal transition observed as the temperature range over which solid transforms to liquid using calibrated apparatus. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light induced by chiral molecules in solution at specified concentration and wavelength. |
| Heavy Metals (as Pb) | Atomic Absorption Spectroscopy (AAS) | Quantification of total heavy metals after acid digestion by measuring absorbance of atomic vapor at characteristic wavelengths. |
| Residue on Ignition | Gravimetric Analysis (Sulfated Ash) | Mass of non-volatile inorganic residue remaining after high-temperature incineration in presence of sulfuric acid. |
| Chloride Impurity | Ion Chromatography (IC) with conductivity detection | Separation and quantification of chloride anions using anion-exchange column and suppressed conductivity detection. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Determination of hydrogen ion activity in a saturated aqueous suspension using calibrated pH electrode and meter. |
Technical Specifications of 4-Pyridyl acetone
| Test Item | Specification |
|---|---|
| Appearance | Yellow-brown liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Refractive Index (n20/D) | 1.520–1.530 |
| Odor | Characteristic odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Pyridyl acetone
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Pyridyl acetone
Packaging of 4-Pyridyl acetone
Industrial 4-Pyridyl acetone Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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