2-CHLORO-4'-HYDROXYACETOPHENONE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 6305-04-0 |
| Product name | 2-CHLORO-4'-HYDROXYACETOPHENONE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-CHLORO-4'-HYDROXYACETOPHENONE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-CHLORO-4'-HYDROXYACETOPHENONE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-CHLORO-4'-HYDROXYACETOPHENONE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesizing antifungal agents (e.g., clotrimazole, miconazole, and other imidazole derivatives) | Prepared via Friedel–Crafts acylation, followed by chlorination and hydrolysis to introduce chloro and hydroxyl functional groups for subsequent imidazole ring construction |
| Agrochemicals | Building block for synthesizing fungicides or plant growth regulators | Serves as an aromatic ketone moiety in condensation or substitution reactions to construct biologically active molecular scaffolds |
| Organic Synthesis | Intermediate for synthesizing fragrances, liquid crystal materials, and functional polymers | Undergoes nucleophilic substitution, coupling reactions (e.g., Suzuki coupling), or protection–deprotection strategies using the hydroxyl and chloro substituents on the aromatic ring to build complex molecules |
Manufacturing Quality Control of 2-CHLORO-4'-HYDROXYACETOPHENONE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~280 nm, comparing peak area against a certified reference standard. |
| Related Substances (Impurities) | HPLC-UV or UPLC-MS | Separation and semi-quantitative/quantitative detection of structurally related impurities (e.g., starting materials, isomers, dehalogenated by-products) using gradient elution and UV or mass-selective detection. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., acetone, methanol, dichloromethane) per ICH Q3C guidelines. |
| Heavy Metals (as Pb) | ICP-OES | Multi-element quantification of toxic metals (Pb, Cd, Hg, As) after acid digestion, based on atomic emission intensity at characteristic wavelengths. |
| Chloride Content | Potentiometric Titration with AgNO₃ | Direct titration with silver nitrate using a silver indicator electrode; endpoint detected by potential inflection due to AgCl precipitation. |
| Moisture Content | Karl Fischer Coulometric Titration | Electrochemical generation of titrant (I₂) proportional to water content; precise quantification of trace water in solid samples. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement via controlled heating; onset and range compared to pharmacopeial reference (e.g., USP/EP). |
| Appearance & Color | Visual Inspection / APHA Color Scale | Subjective assessment of crystalline form and color intensity against platinum-cobalt standards per ASTM D1209. |
| Residue on Ignition | Gravimetric Analysis (Weight Loss on Ignition) | High-temperature ashing (700–800 °C) followed by weighing of inorganic residue to assess non-volatile inorganic impurities. |
| pH of Aqueous Suspension | pH Meter Measurement | pH determination of a saturated aqueous suspension (e.g., 1% w/v) using calibrated pH electrode; indicates acidic/basic degradation products. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion using Mie scattering theory to determine D10, D50, D90 values relevant for filtration and formulation. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light through a solution; confirms chiral purity (though compound is achiral, detects chiral contaminants). |
Technical Specifications of 2-CHLORO-4'-HYDROXYACETOPHENONE
| Test Item | Specification |
|---|---|
| Appearance | Orange crystalline powder |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 82–86°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-CHLORO-4'-HYDROXYACETOPHENONE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-CHLORO-4'-HYDROXYACETOPHENONE
Safety Information of 2-CHLORO-4'-HYDROXYACETOPHENONE
| Pictograms |   |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 2-CHLORO-4'-HYDROXYACETOPHENONE
Industrial 2-CHLORO-4'-HYDROXYACETOPHENONE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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