Cefotaxime Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 63527-52-6 |
| Product name | Cefotaxime |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Cefotaxime
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Cefotaxime Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Cefotaxime
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Raw material for cefotaxime sodium synthesis | Chemical synthesis; acylation reaction |
| Pharmaceutical Industry | Antibiotic intermediate | Hydroxyl group protection and deprotection |
| Pharmaceutical R&D | Drug analysis and quality control | Reference standard preparation; purification process |
Manufacturing Quality Control of Cefotaxime
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection + Physical Property Determination | Observe sample color and state (typically white or off-white powder), and determine solubility (readily soluble in water and methanol, poorly soluble in ether) |
| Identification | Infrared Spectroscopy (IR) | Compare infrared spectrum with reference standard of cefotaxime acid; characteristic absorption peaks (e.g., β-lactam ring at 1770 cm⁻¹, carboxylic acid at 1710 cm⁻¹) should match |
| High-Performance Liquid Chromatography (HPLC) | Confirm identity by comparing retention time with reference standard; commonly uses C18 column and mobile phase composed of methanol-water/buffer salt system | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Quantify using external or internal standard method, with UV detection at 254 nm or 265 nm; calculate percentage of main peak area, meeting pharmacopoeial requirements (e.g., ≥95.0%) |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use gradient elution to separate degradation products (e.g., desacetyl cefotaxime, dimer), detect at 254 nm; individual impurity ≤1.0%, total impurities ≤3.0% |
| Residual Solvents | Gas Chromatography (GC) | Headspace injection used to detect residual solvents such as methanol, ethanol, acetone, dichloromethane; limits controlled according to ICH Q3C guidelines |
| Water Content | Karl Fischer Titration | Precisely measure moisture content; typically required to be ≤5.0% to ensure product stability and storage safety |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Detect levels of heavy metals such as lead, cadmium, mercury, arsenic; comply with pharmacopoeial limits (e.g., lead ≤10 ppm) |
| Particle Size Distribution (if applicable) | Laser Diffraction or Microscopy | For powdered active pharmaceutical ingredients, measure particle size distribution to ensure uniformity and compressibility (e.g., D90 < 50 μm) |
| pH Value (Solution) | pH Meter Measurement | Prepare aqueous solution at specified concentration (e.g., 10 mg/mL), measure pH range (typically 4.0–7.0), reflecting acid-base stability |
| Microbial Limits | Plate Count Method / MPN Method | Test for total aerobic microbial count, molds and yeasts, and presence of *Escherichia coli*; meet microbial limits for non-sterile APIs (e.g., ≤10³ CFU/g) |
| Pyrogens or Bacterial Endotoxins | Limulus Amebocyte Lysate Test (LAL Test) | Determine bacterial endotoxin levels; typically required to be <5.0 EU/mg (based on injectable requirements; for API, consider final formulation specifications) |
Technical Specifications of Cefotaxime
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178-182°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Optical Rotation | -40° to -46° (c=1, in water) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Cefotaxime
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Cefotaxime
Packaging of Cefotaxime
Industrial Cefotaxime Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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