8-Bromoisoquinoline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 63927-22-0 |
| Product name | 8-Bromoisoquinoline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 8-Bromoisoquinoline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 8-Bromoisoquinoline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 8-Bromoisoquinoline
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Organic synthesis intermediate for constructing biologically active molecules containing the isoquinoline scaffold (e.g., kinase inhibitors, antitumor compounds) | Used in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) or as an electrophile in heterocycle functionalization |
| Agrochemical R&D | Structural building block for novel insecticides/fungicides, applied to modify heterocyclic agrochemical molecules to optimize physicochemical properties and target-site activity | Applied in halogen exchange or transition metal-catalyzed C–N/C–C bond formation to introduce specific substituents that enhance agricultural activity |
| Materials Science | Precursor for organic optoelectronic functional materials, used to synthesize isoquinoline-based fluorescent dyes or electron-transport materials | Applied in multistep organic synthesis, including cyclization, bromination, coupling, and subsequent heteroatom introduction |
Manufacturing Quality Control of 8-Bromoisoquinoline
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies 8-bromoisoquinoline by separation on a reversed-phase column and UV detection at ~254 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., unreacted isoquinoline, bromination by-products) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Identifies and quantifies residual solvents (e.g., DMF, toluene, methanol) via headspace gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines trace water content electrochemically by iodine–sulfur dioxide redox reaction in a methanolic pyridine-based reagent. |
| Heavy Metals | ICP-MS | Measures trace metal contaminants (e.g., Pd, Ni, Fe) after acid digestion using inductively coupled plasma mass spectrometry for ultra-trace sensitivity. |
| Chloride Impurity | Ion Chromatography (IC) | Separates and quantifies chloride ions using anion-exchange column with suppressed conductivity detection. |
| Melting Point | Capillary Melting Point Apparatus | Determines purity-dependent solid-phase transition temperature by controlled heating of a capillary sample under standardized conditions. |
| Appearance & Color | Visual Inspection / APHA Color Scale | Evaluates physical state (crystalline powder), color (pale yellow to off-white), and absence of visible particulates or discoloration. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic residue after high-temperature ashing (700–800 °C) and subsequent weighing. |
| Specific Optical Rotation | Polarimetry | Measures chiral purity (if applicable) via rotation of plane-polarized light in solution; typically near zero for achiral 8-bromoisoquinoline. |
| Particle Size Distribution | Laser Diffraction | Determines granulometric profile using Mie scattering theory applied to dispersed particles in air or liquid medium. |
| Bulk & Tapped Density | ASTM D6393 | Measures volumetric mass properties using standardized tapping and free-fall methods to assess flowability and compressibility. |
| Organic Volatile Impurities (OVI) | GC-MS | Screens for genotoxic or highly volatile impurities (e.g., alkyl bromides, bromoform) using gas chromatography coupled with mass spectrometric identification. |
| Sulfated Ash | Gravimetric Analysis | Quantifies inorganic sulfate residues after sulfuric acid treatment and high-temperature incineration, per USP <281>. |
Technical Specifications of 8-Bromoisoquinoline
| Test Item | Specification |
|---|---|
| Appearance | Yellow-brown solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 78–82°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 8-Bromoisoquinoline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 8-Bromoisoquinoline
Packaging of 8-Bromoisoquinoline
Industrial 8-Bromoisoquinoline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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