N-Benzyloxycarbonyl-D-proline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 6404-31-5 |
| Product name | N-Benzyloxycarbonyl-D-proline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Benzyloxycarbonyl-D-proline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Benzyloxycarbonyl-D-proline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Benzyloxycarbonyl-D-proline
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Amino acid protecting group for peptide synthesis | Used to protect the amino group of D-proline with an N-benzyloxycarbonyl (Z) group in solid-phase or solution-phase peptide synthesis, preventing side reactions; deprotection is subsequently achieved via hydrogenolysis or acidic cleavage |
| Pharmaceuticals | Intermediate for protease inhibitors and antiviral drugs | Employed as a chiral building block in constructing proline-containing drug molecules, such as HIV protease inhibitors |
| Chemical Synthesis | Synthesis of chiral ligands and catalysts | Applied in preparing chiral ligands for asymmetric catalysis, including metal complex precursors used in hydrogenation or epoxidation reactions |
| R&D | Organic synthesis intermediate | Utilized as a starting material for constructing complex molecules containing a proline scaffold at laboratory scale, followed by further derivatization via coupling, cyclization, and related reactions |
Manufacturing Quality Control of N-Benzyloxycarbonyl-D-proline
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment using a chiral stationary phase to resolve D- and L-isomers; D-isomer content calculated from peak area ratio. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine-based reagent where water reacts stoichiometrically, enabling precise quantification by endpoint detection. |
| Residual Solvents | GC-FID | Separation and quantification of volatile organic solvents (e.g., methanol, ethyl acetate) using gas chromatography with flame ionization detection. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pb, Cd, Hg, As) via inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column and suppressed conductivity detection. |
| Sulfated Ash | Gravimetric Analysis | Incineration at 700-800 C followed by sulfuric acid treatment and weighing of residual inorganic ash. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light to confirm stereochemical identity and enantiomeric integrity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition determination by observing solid-to-liquid phase change under controlled heating rate. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of foreign particles under standardized lighting and against white/black background. |
| pH of Aqueous Solution | pH Meter | Measurement of hydrogen ion activity in a 1% w/v aqueous suspension using calibrated glass electrode. |
| Related Substances | HPLC-UV (Forced Degradation) | Detection and quantification of structurally related impurities (e.g., hydrolysis/decarboxylation products) using stability-indicating gradient HPLC method. |
Technical Specifications of N-Benzyloxycarbonyl-D-proline
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Melting Point | 128.0 to 132.0 °C |
| Optical Rotation | +37.0 to +43.0 ° (c=1, in DMF) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Benzyloxycarbonyl-D-proline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Benzyloxycarbonyl-D-proline
Safety Information of N-Benzyloxycarbonyl-D-proline
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-Benzyloxycarbonyl-D-proline
Industrial N-Benzyloxycarbonyl-D-proline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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