China Factory Direct
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| CAS number | 645-65-8 |
| Product name | Imidazole-4-acetic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of antifungal drug intermediates | Used as a building block for imidazole derivatives, enabling ring system modification and functionalization of drug molecules |
| Chemical Research | Organic synthesis reagent | Applied in the preparation of functional ligands or nitrogen-containing heterocyclic structures in metal–organic frameworks (MOFs) |
| Biochemistry | Biologically active molecule research | Employed in experimental designs simulating imidazole metabolic pathways in biological systems, supporting enzyme inhibitor screening |
| Detection Item | Common Analytical Method | Method Overview |
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| Assay (Purity) | Acid-Base Titration with NaOH | Quantifies imidazole-4-acetic acid content based on stoichiometric neutralization of the carboxylic acid group. |
| Water Content | Karl Fischer Titration | Determines trace water by electrochemical or volumetric reaction with iodine, sulfur dioxide, and base in methanol. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic impurities remaining after high-temperature ashing. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) | Quantifies metal contaminants (e.g., Pb, Cd, Hg) by atomic absorption of characteristic wavelengths in flame or graphite furnace. |
| Chloride Impurity | Ion Chromatography (IC) | Separates and quantifies chloride ions using anion-exchange column and conductivity detection. |
| Sulfate Impurity | Barium Sulfate Gravimetry | Precipitates sulfate as BaSO4 and determines mass after filtration and drying. |
| Related Substances | Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) | Separates and quantifies structurally related impurities using C18 column and UV detection. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid, indicating purity and identity. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Drying | Measures mass loss upon heating under controlled conditions to assess volatile content. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Determines hydrogen ion activity in a defined aqueous suspension or solution using calibrated pH electrode. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of foreign particles against established reference standards. |
| Specific Optical Rotation | Polarimetry | Measures rotation of plane-polarized light to confirm chiral integrity and detect enantiomeric impurities. |
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148-152°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.