1-tert-butyl 2-methyl (2R,4R)-4-fluoropyrrolidine-1,2-dicarboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 647857-43-0 |
| Product name | 1-tert-butyl 2-methyl (2R,4R)-4-fluoropyrrolidine-1,2-dicarboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum200L/drum1000L/IBC |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 647857-43-0
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 647857-43-0 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 647857-43-0
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Synthesis of peptide-based drug intermediates | Used to construct fluoroproline-containing peptide structures to enhance drug stability and bioavailability |
| Chemical Synthesis | Key raw material for peptide synthesis | Introduced as a fluorinated modified amino acid into peptide chains during solid-phase or solution-phase peptide synthesis |
| Biopharmaceuticals | Development of antitumor and antiviral drugs | Enhances molecular affinity for target sites and metabolic stability through fluorine atom incorporation |
| Fine Chemicals | Construction of high-value functional molecules | Applied in designing novel organic molecules with specific conformations or biological activity |
| Molecular Probe Research | Construction of fluorescently or isotopically labeled compounds | Serves as a fluorine-18 labeling precursor or structural template for positron emission tomography (PET) studies |
Manufacturing Quality Control of 647857-43-0
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210 nm. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase; quantification based on relative peak areas of R and S isomers. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, dichloromethane) against calibration standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine generated electrochemically to react stoichiometrically with water in the sample. |
| Heavy Metals | ICP-MS | Quantitative determination of trace metal impurities (e.g., Pb, Cd, Ni) after acid digestion, using inductively coupled plasma mass spectrometry. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride anions using suppressed conductivity detection after elution with carbonate/bicarbonate buffer. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., hydrolysis products, diastereomers) using gradient reversed-phase HPLC. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using a polarimeter at 20 degC with sodium D-line (589 nm) light source. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as the temperature range over which solid-to-liquid phase change occurs under controlled heating rate. |
| Residue on Ignition | Gravimetric Analysis | Mass loss upon high-temperature ashing (700-800 degC) followed by weighing of non-volatile inorganic residue. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of the substance in solution or solid form under controlled lighting conditions. |
| pH (1% w/v aqueous solution) | pH Meter | Electrochemical measurement of hydrogen ion activity using calibrated glass electrode in a standardized aqueous suspension. |
Technical Specifications of 647857-43-0
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 85.0–89.0°C |
| Optical Rotation | +22.0° to +26.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 647857-43-0
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 647857-43-0
Packaging of 647857-43-0
Industrial 647857-43-0 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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