Theophylline-7-acetic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 652-37-9 |
| Product name | Theophylline-7-acetic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Theophylline-7-acetic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Theophylline-7-acetic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Theophylline-7-acetic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Intermediate in the synthesis of xanthine-based drugs | Used to produce ester compounds via reaction of acetic acid with theophylline |
| Chemical Synthesis Industry | Preparation of other theophylline derivatives | Applied as a reagent in esterification reactions during organic synthesis |
| Agricultural Chemicals Industry | Synthesis of certain herbicides or plant growth regulators | Employed as an intermediate in chemical synthesis processes |
Manufacturing Quality Control of Theophylline-7-acetic acid
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Assay | High-Performance Liquid Chromatography (HPLC) | Uses a C18 column with methanol-water or acetonitrile-buffer solution as the mobile phase. Detection is performed using a UV detector (around 270 nm), and the theophylline content is calculated by external standard method. This method offers high specificity and accuracy. |
| Purity and Related Substances | High-Performance Liquid Chromatography (HPLC) | Based on the assay method, a gradient elution program is optimized to separate and detect degradation products (e.g., caffeine, by-products) in theophylline. The total impurity and individual impurity levels are then calculated. |
| Identification | UV-Visible Spectrophotometry (UV-Vis) | Measures the characteristic absorption peak of the sample between 270–275 nm. Comparison of the maximum absorption wavelength with that of the reference standard is used for preliminary identification. |
| Infrared Spectroscopy (IR) | The sample is pressed into a pellet with potassium bromide, and the infrared absorption spectrum is recorded. Functional group peaks (such as C=O, N-H, aromatic rings) are compared with a standard spectrum to confirm structural consistency. | |
| Residual Solvents | Gas Chromatography (GC) | Uses a capillary column and FID detector to analyze residual organic solvents (e.g., methanol, ethanol, acetone, ethyl acetate) from manufacturing processes, ensuring compliance with ICH Q3C guidelines. |
| Moisture Content | Karl Fischer Titration | Determines water content precisely based on the quantitative reaction of iodine with sulfur dioxide in a pyridine/methanol system. Suitable for moisture control in active pharmaceutical ingredients (APIs). |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After sample digestion, determines the levels of heavy metal elements such as lead, cadmium, mercury, and arsenic to ensure compliance with pharmacopeial safety limits. |
| Crystal Form Analysis | X-Ray Powder Diffraction (XRD) | Analyzes the crystal structure of the sample to identify polymorphic forms, which is important for controlling formulation stability and dissolution properties. |
| Particle Size Distribution | Laser Particle Size Analysis | Measures the particle size distribution of the API using laser light scattering principles, which influences dissolution rate and bioavailability. |
| Residual Acetic Acid (if applicable) | Gas Chromatography (GC) or Ion Chromatography (IC) | Detects residual acetic acid or acetate ions in the sample, particularly necessary when acetic anhydride or acetic acid is used as a solvent or reagent during synthesis. |
Technical Specifications of Theophylline-7-acetic acid
| Test Item | Specification |
|---|---|
| Appearance | White to almost white powder or crystals |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 267-271°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Theophylline-7-acetic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Theophylline-7-acetic acid
Packaging of Theophylline-7-acetic acid
Industrial Theophylline-7-acetic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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