Methyl 4,6-dichloronicotinate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 65973-52-6 |
| Product name | Methyl 4,6-dichloronicotinate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Methyl 4,6-dichloronicotinate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Methyl 4,6-dichloronicotinate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Methyl 4,6-dichloronicotinate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of antiviral agents (e.g., non-nucleoside reverse transcriptase inhibitors) | Used as a key building block in drug synthesis to construct complex molecular frameworks via subsequent reactions |
| Agrochemicals | Intermediate in the preparation of insecticides or herbicides | Applied in active ingredient synthesis to introduce nitrogen-containing heterocyclic structures, thereby enhancing biological activity |
| Research | Organic synthesis intermediate for experimental studies | Used in laboratory-scale synthesis of nicotinic acid derivatives or reaction studies involving chlorinated heterocyclic compounds |
Manufacturing Quality Control of Methyl 4,6-dichloronicotinate
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 220-230 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., mono-chloro analogs, hydrolysis products, residual solvents) using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., methanol, dichloromethane, toluene) using gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Electrochemical titration with iodine-based reagent to determine trace water content based on stoichiometric reaction with water. |
| Heavy Metals | ICP-OES | Multi-element quantification of toxic metals (e.g., Pb, Cd, As, Hg) after acid digestion, using inductively coupled plasma optical emission spectrometry. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode; endpoint detected by potential change due to AgCl precipitation. |
| Acid Value | Acid-Base Titration | Neutralization of free acid impurities (e.g., 4,6-dichloronicotinic acid) with standardized NaOH solution using phenolphthalein or potentiometric endpoint. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity of the sample against established visual standards under controlled lighting conditions. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating purity and identity via comparison to reference material. |
| Loss on Drying | Gravimetric Analysis | Measurement of mass loss after drying under specified vacuum/temperature conditions to assess volatile and moisture content. |
| Residue on Ignition | Sulfated Ash Gravimetry | Determination of non-volatile inorganic residue after high-temperature incineration following sulfuric acid treatment. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation of plane-polarized light to confirm chiral purity and absence of racemization (though compound is achiral, used for consistency). |
Technical Specifications of Methyl 4,6-dichloronicotinate
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 62–66°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Methyl 4,6-dichloronicotinate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Methyl 4,6-dichloronicotinate
Safety Information of Methyl 4,6-dichloronicotinate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of Methyl 4,6-dichloronicotinate
Industrial Methyl 4,6-dichloronicotinate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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